Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
| ▸ | HTR2B | P41595 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 9/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.43 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.43 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.43 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.43 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9585712 | 0.88 | KCNH2 (0.53) | HTR2AHTR2CHTR2BKCNH2CYP3A4 | |
| SCHEMBL9444257 | 0.87 | KCNH2 (0.60) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9472066 | 0.84 | ADRB1 (0.53) | HTR2AHTR2CHTR2BKCNH2CYP3A4 | |
| SCHEMBL8958724 | 0.82 | SMN1; SMN2 (0.63) | HTR2AHTR2CKCNH2CYP3A4CYP2D6 | |
| SCHEMBL8958783 | 0.82 | KCNH2 (0.55) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| Hydrochloric Acid SCHEMBL9077228 | 0.81 | KCNH2 (0.56) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| Hydrochloric Acid SCHEMBL9077240 | 0.81 | KCNH2 (0.56) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9079271 | 0.81 | KCNH2 (0.56) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9077354 | 0.80 | KCNH2 (0.56) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| Hydrochloric Acid SCHEMBL9227219 | 0.79 | KCNH2 (0.56) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0235752-B1 | Piperidine derivative, pharmaceutical composition containing the same and use | EISAI CO LTD (JP) | 1993-11-18 | — | — | EP | disclosed |
| US-5179095-A | Antiarrhythmia agents | EISAI CO., LTD. (JP) | 1993-01-12 | — | — | US | disclosed |
| US-5118689-A | Antiarrhythmia agents | EISAI CO., LTD. (JP) | 1992-06-02 | — | — | US | disclosed |
| US-4996215-A | Antiarrythmia agents | EISAI CO., LTD. (JP) | 1991-02-26 | — | — | US | disclosed |
| US-4876262-A | ANTIARRHYTHMIA AGENTS | EISAI CO., LTD. (JP) | 1989-10-24 | — | — | US | disclosed |
| EP-0235752-A2 | Piperidine derivative, pharmaceutical composition containing the same and use | Eisai Co., Ltd. (JP) | 1987-09-09 | — | — | EP | disclosed |