Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL702504 | 0.91 | NPSR1 (0.47) | NPSR1KCNH2EGFRTSHRPOLB | |
| SCHEMBL10772790 | 0.86 | NPSR1 (0.39) | NPSR1KCNH2EGFRTSHRPOLB | |
| SCHEMBL12212067 | 0.84 | NPSR1 (0.42) | NPSR1KCNH2EGFRTSHRPOLB | |
| SCHEMBL10770711 | 0.83 | CYP4F2 (0.39) | NPSR1KCNH2EGFRTSHRPOLB | |
| SCHEMBL2008228 | 0.82 | NPSR1 (0.41) | NPSR1KCNH2EGFRTSHRPOLB | |
| SCHEMBL916350 | 0.80 | CCNT1 (0.43) | NPSR1KCNH2EGFRTSHRPOLB | |
| SCHEMBL25410688 | 0.79 | EGFR (0.40) | NPSR1KCNH2EGFRTSHRPOLB | |
| SCHEMBL914783 | 0.79 | TSHR (0.41) | TSHRPOLB | |
| SCHEMBL9849219 | 0.79 | NPSR1 (0.41) | NPSR1KCNH2EGFRTSHRPOLB | |
| SCHEMBL4538982 | 0.79 | KCNH2 (0.43) | NPSR1KCNH2EGFRTSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5179085-A | Cerebrovascular disorders | WARNER-LAMBERT COMPANY (US) | 1993-01-12 | — | — | US | disclosed |
| US-5177240-A | Treatment to reduce neurotoxic injury | G. D. SEARLE & CO. (US) | 1993-01-05 | — | — | US | disclosed |
| EP-0364996-A2 | Phosphono-hydroisoquinoline compounds useful in reducing neurotoxic injury | G.D. Searle & Co. (US) | 1990-04-25 | — | — | EP | disclosed |
| EP-0242709-A2 | Antagonists of specific excitatory amino acid neurotransmitter receptors | NOVA PHARMACEUTICAL CORPORATION (US) | 1987-10-28 | — | — | EP | disclosed |
| WO-1987006131-A1 | ANTAGONISTS OF SPECIFIC EXCITATORY AMINO ACID NEUROTRANSMITTER RECEPTORS | RZESZOTARSKI JANUSZ WACLAW (US) | 1987-10-22 | — | — | WO | disclosed |
| US-4657899-A | ANALGESICS, COGNITION ACTIVATORS | NOVA PHARMACEUTICAL CORPORATION (US) | 1987-04-14 | — | — | US | disclosed |