Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.35 |
| ▸ | THRA | P10827 | 5/20 | 0.33 |
| ▸ | THRB | P10828 | 5/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 2/20 | 0.31 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28084243 | 0.98 | SCD (0.41) | SCDMEN1KMT2AHIF1AEPAS1 | |
| SCHEMBL28102844 | 0.98 | SCD (0.41) | SCDMEN1KMT2AHIF1AEPAS1 | |
| SCHEMBL16976827 | 0.77 | — | — | |
| SCHEMBL678379 | 0.77 | MEN1 (0.42) | SCDMEN1KMT2AHIF1ATHRB | |
| SCHEMBL20339953 | 0.77 | MEN1 (0.42) | SCDMEN1KMT2AHIF1ATHRB | |
| SCHEMBL17634359 | 0.75 | — | — | |
| SCHEMBL29482108 | 0.74 | SCD (0.33) | SCDHIF1AEPAS1 | |
| SCHEMBL29482107 | 0.74 | SCD (0.33) | SCDHIF1AEPAS1 | |
| SCHEMBL29482102 | 0.74 | SCD (0.33) | SCDHIF1AEPAS1 | |
| SCHEMBL822308 | 0.74 | SCD (0.43) | SCDMEN1KMT2AHIF1ATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111801327-B | Benzamide compounds | 里科瑞尔姆IP控股有限责任公司 | 2024-02-09 | — | — | CN | disclosed |
| CN-115461335-A | BCL-2 protein inhibitors | 里科瑞尔姆IP控股有限责任公司 | 2022-12-09 | — | — | CN | disclosed |
| CN-114126616-A | Nanoparticle formulations of BCL-2 inhibitors | 里科瑞尔姆IP控股有限责任公司 | 2022-03-01 | — | — | CN | disclosed |
| CN-106008466-B | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | 艾伯维公司 | 2018-12-14 | — | — | CN | disclosed |
| CN-106008322-B | sulfonamide derivatives as BC L-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases | ABBVIE 公司 | 2018-09-04 | — | — | CN | disclosed |
| CN-107922409-A | HETEROARYL DERIVATIVES AS PARP INHIBITORS | 鲁宾有限公司 | 2018-04-17 | — | — | CN | disclosed |
| CN-107253963-A | Pyridone and azepine pyridinone compounds and application method | 吉利德康涅狄格有限公司 | 2017-10-17 | — | — | CN | disclosed |
| CN-107011348-A | It is used as the heteroaryl pyridines ketone and azepine pyridinone compounds of the inhibitor of BTK activity | 霍夫曼-拉罗奇有限公司 | 2017-08-04 | — | — | CN | disclosed |
| CN-106922146-A | Pyrazole carboxamide compounds for the treatment of diseases mediated by Bruton's tyrosine kinase (BTK) | 豪夫迈·罗氏有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103038233-B | Pyridone and azapyridone compounds and methods of use | 吉利德康涅狄格有限公司 | 2017-06-20 | — | — | CN | disclosed |
| CN-104125959-B | Heteroaryl pyridone and aza-pyridone compounds as inhibitors of BTK activity | 霍夫曼-拉罗奇有限公司 | 2017-05-03 | — | — | CN | disclosed |
| CN-106397418-A | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBVIE公司 | 2017-02-15 | — | — | CN | disclosed |
| CN-104024255-B | Alkylated piperazine compounds as inhibitors of BTK activity | 霍夫曼-拉罗奇有限公司 | 2017-01-18 | — | — | CN | disclosed |
| CN-104105697-B | Bicyclic piperazines compound | 霍夫曼-拉罗奇有限公司 | 2016-11-09 | — | — | CN | disclosed |
| CN-106008466-A | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | 艾伯维公司 | 2016-10-12 | — | — | CN | disclosed |
| CN-106008322-A | BCL-2-selectively apoptosis-inducing agents for the treatment of cancer and immune diseases | ABBVIE 公司 | 2016-10-12 | — | — | CN | disclosed |
| CN-102307622-B | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | 艾伯维公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-104024255-A | Alkylated piperazine compounds as inhibitors of BTK activity | HOFFMANN LA ROCHE | 2014-09-03 | — | — | CN | disclosed |
| US-5258544-A | Synthesis of aldehydes useful in the preparations of HMG-CoA reductase inhibitors | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1993-11-02 | — | — | US | disclosed |
| US-5258544-A | Synthesis of aldehydes useful in the preparations of HMG-CoA reductase inhibitors | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1993-11-02 | — | — | US | disclosed |