Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 8/20 | 0.80 |
| ▸ | RARA | P10276 | 7/20 | 0.80 |
| ▸ | RARB | P10826 | 6/20 | 0.80 |
| ▸ | RARG | P13631 | 6/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.80 |
| ▸ | MEN1 | O00255 | 2/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.80 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.80 |
| ▸ | TSHR | P16473 | 1/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.80 |
| ▸ | CYP26B1 | Q9NR63 | 5/20 | 0.70 |
| ▸ | PGR | P06401 | 1/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.67 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.67 |
| ▸ | BLVRB | P30043 | 1/20 | 0.67 |
| ▸ | NQO2 | P16083 | 2/20 | 0.51 |
| ▸ | RXRA | P19793 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9446497 | 0.91 | RARA (0.67) | CYP26A1RARARARBRARGCYP3A4 | |
| SCHEMBL8461840 | 0.91 | CYP26A1 (0.80) | CYP26A1RARARARBRARGCYP3A4 | |
| SCHEMBL9747060 | 0.91 | RARA (0.67) | CYP26A1RARARARBRARGCYP3A4 | |
| SCHEMBL8459704 | 0.89 | RARA (0.80) | CYP26A1RARARARBRARGCYP3A4 | |
| SCHEMBL726740 | 0.89 | RARB (1.00) | CYP26A1RARARARBRARGCYP3A4 | |
| SCHEMBL29355626 | 0.89 | RARB (1.00) | CYP26A1RARARARBRARGCYP3A4 | |
| SCHEMBL9446600 | 0.87 | RARA (0.78) | CYP26A1RARARARBRARGCYP3A4 | |
| SCHEMBL1616121 | 0.87 | CYP26A1 (0.78) | CYP26A1RARARARBRARGCYP3A4 | |
| SCHEMBL1616078 | 0.87 | CYP26A1 (0.78) | CYP26A1RARARARBRARGCYP3A4 | |
| SCHEMBL7621355 | 0.87 | RARA (0.82) | CYP26A1RARARARBRARGCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0410358-B1 | AROMATIC CARBOXYLIC ACID AMIDES, THEIR PREPARATION AND THEIR USE AS MEDICINES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-09-29 | — | — | EP | claimed |
| US-5128470-A | Aantiinflammatory, antiallergens | HOFFMANN-LA ROCHE INC. (US) | 1992-07-07 | — | — | US | claimed |
| US-5216153-A | Therapy and prophylaxis for skin, autoimmune and rheumatic diseases | HOFFMANN-LA ROCHE INC. (US) | 1993-06-01 | — | — | US | disclosed |
| US-5128470-A | Aantiinflammatory, antiallergens | HOFFMANN-LA ROCHE INC. (US) | 1992-07-07 | — | — | US | disclosed |