Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | CCR8 | P51685 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15868176 | 0.87 | IRAK4 (0.40) | IRAK4MAP4K4MEN1KMT2AALDH1A1 | |
| SCHEMBL16130221 | 0.85 | MAP4K4 (0.46) | IRAK4MAP4K4HTTRECQLCCR1 | |
| SCHEMBL15587862 | 0.82 | MAP4K4 (0.43) | IRAK4MAP4K4HTTRECQLCCR1 | |
| SCHEMBL19226473 | 0.82 | MAP4K4 (0.43) | IRAK4MAP4K4HTTRECQLCCR1 | |
| SCHEMBL17886900 | 0.79 | MAP4K4 (0.45) | IRAK4MAP4K4HTTRECQLCCR1 | |
| SCHEMBL102150 | 0.78 | CCR1 (0.50) | MAP4K4HTTRECQLCCR1CCR8 | |
| SCHEMBL23226823 | 0.78 | KCNH2 (0.40) | IRAK4MAP4K4SMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL15890717 | 0.76 | MAP4K4 (0.46) | IRAK4MAP4K4HTTRECQLCCR1 | |
| SCHEMBL23666724 | 0.76 | RAB9A (0.43) | MAP4K4HTTRECQLRAB9AFDPS | |
| SCHEMBL954513 | 0.75 | CCR1 (0.52) | MAP4K4HTTRECQLCCR1CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024107393-A1 | TRICYCLIC COMPOUNDS | SCHRÖDINGER, INC. (US) | 2024-05-23 | — | — | WO | disclosed |
| EP-2855459-B1 | AMINOQUINAZOLINE AND PYRIDOPYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2020-04-29 | — | — | EP | disclosed |
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |
| US-9873709-B2 | Triazolopyridine compounds, compositions and methods of use thereof | GENENTECH, INC. (US) | 2018-01-23 | — | — | US | disclosed |
| US-20170226132-A1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-08-10 | — | — | US | disclosed |
| US-9592235-B2 | Aminoquinazoline and pyridopyrimidine derivatives | GENENTECH, INC. (US) | 2017-03-14 | — | — | US | disclosed |
| US-20160296525-A1 | AMINOQUINAZOLINE AND PYRIDOPYRIMIDINE DERIVATIVES | GENENTECH, INC. (US) | 2016-10-13 | — | — | US | disclosed |
| US-9382241-B2 | Aminoquinazoline and pyridopyrimidine derivatives | GENENTECH, INC. (US) | 2016-07-05 | — | — | US | disclosed |
| US-20160185780-A1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2016-06-30 | — | — | US | disclosed |
| US-5246946-A | Antiarrhythmia agents and cardiovascular disorders | EISAI CO., LTD. (JP) | 1993-09-21 | — | — | US | disclosed |
| EP-0304888-B1 | SULFONAMIDOLPHENYL DERIVATES AND THERAPEUTIC AND PREVENTIVE AGENTS FOR ARRYTHMIA CONTAINING SAME | Eisai Co., Ltd. (JP) | 1992-11-11 | — | — | EP | disclosed |
| US-5162347-A | Piperidine derivatives and therapeutic and preventive agents for arrhythmia containing same | EISAI CO., LTD. (JP) | 1992-11-10 | — | — | US | disclosed |
| US-5082850-A | PIPERIDINE DERIVATIVES AND THERAPEUTIC AND PREVENTIVE AGENTS FOR ARRHYTHMIA CONTAINING SAME | EISAI CO., LTD. (JP) | 1992-01-21 | — | — | US | disclosed |
| US-4977165-A | Piperidine derivative and therapeutic and preventive agents for arrhythmia containing same | EISAI CO., LTD. (JP) | 1990-12-11 | — | — | US | disclosed |
| EP-0304888-A1 | Sulfonamidolphenyl derivates and therapeutic and preventive agents for arrythmia containing same | Eisai Co., Ltd. (JP) | 1989-03-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160185780-A1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | ABL1, JAK2, JAK1 | IRAK4 259/4885MAP4K4 27/4885HTT 4749/4885 |
| US-20160296525-A1 | AMINOQUINAZOLINE AND PYRIDOPYRIMIDINE DERIVATIVES | DPYD, FANCD2, RECQL | IRAK4 1358/4885MAP4K4 700/4885HTT 4454/4885 |
| US-20170226132-A1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | ABL1, JAK2, JAK1 | IRAK4 259/4885MAP4K4 27/4885HTT 4749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.