SCHEMBL9447665

SCHEMBL9447665

CC(C)(C)c1cc(Cc2cc(S)ccn2)cc(C(C)(C)C)c1O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHFR P00374 1/20 0.44
GAA P10253 3/20 0.43
MEN1 O00255 4/20 0.42
KMT2A Q03164 4/20 0.42
ALDH1A1 P00352 8/20 0.41
TSHR P16473 3/20 0.41
LMNA P02545 2/20 0.41
MAPK1 P28482 3/20 0.41
CYP1A2 P05177 2/20 0.41
CYP3A4 P08684 2/20 0.41
BLM P54132 2/20 0.41
ATM Q13315 2/20 0.41
HIF1A Q16665 2/20 0.41
NPSR1 Q6W5P4 2/20 0.41
GMNN O75496 1/20 0.41
GABBR2 O75899 1/20 0.41
TP53 P04637 1/20 0.41
CYP2C9 P11712 1/20 0.41
ALOX15 P16050 1/20 0.41
NFKB1 P19838 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9447719 0.81 HSPA5 (0.59) DHFRGAAMEN1KMT2AALDH1A1
SCHEMBL9447711 0.73 DHFR (0.44) DHFRGAAMEN1KMT2AALDH1A1
SCHEMBL39559 0.73 ALDH1A1 (0.63) DHFRGAAMEN1KMT2AALDH1A1
SCHEMBL9447685 0.72 DHFR (0.49) DHFRGAAMEN1KMT2AALDH1A1
SCHEMBL28453026 0.72 ALDH1A1 (0.42) DHFRGAAMEN1KMT2AALDH1A1
SCHEMBL9338699 0.71 ALDH1A1 (0.57) DHFRGAAMEN1KMT2AALDH1A1
SCHEMBL11430262 0.71 DHFR (0.50) DHFRGAAMEN1KMT2AALDH1A1
SCHEMBL526641 0.71 ALDH1A1 (0.61) DHFRGAAMEN1KMT2AALDH1A1
Benzene SCHEMBL9807217 0.69 ALDH1A1 (0.59) DHFRGAAMEN1KMT2AALDH1A1
SCHEMBL2292879 0.69 DHFR (0.54) DHFRGAAMEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5190723-A Phenol substituted with thioether compound CIBA-GEIGY CORPORATION (US) 1993-03-02 US claimed
EP-0330613-B1 COMPOSITIONS AND METHOD FOR INHIBITING CORROSION CIBA-GEIGY AG (CH) 1993-08-18 EP disclosed
US-5190723-A Phenol substituted with thioether compound CIBA-GEIGY CORPORATION (US) 1993-03-02 US disclosed
EP-0330613-A2 Compositions and method for inhibiting corrosion CIBA-GEIGY AG (CH) 1989-08-30 EP disclosed