Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 8/20 | 0.62 |
| ▸ | PLA2G2A | P14555 | 6/20 | 0.61 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.61 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | RGS12 | O14924 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL9140709 | 0.99 | ALOX5AP (0.61) | ALOX5APPLA2G2APLA2G1BPTGDR2CYP3A4 | |
| Water SCHEMBL9140717 | 0.99 | ALOX5AP (0.61) | ALOX5APPLA2G2APLA2G1BPTGDR2CYP3A4 | |
| SCHEMBL9140666 | 0.97 | PLA2G2A (0.65) | ALOX5APPLA2G2APLA2G1BPTGDR2CYP3A4 | |
| SCHEMBL2746925 | 0.96 | ALOX5AP (0.68) | ALOX5APPLA2G2APLA2G1BPTGDR2CYP3A4 | |
| Hydrochloric Acid SCHEMBL9138311 | 0.95 | ALOX5AP (0.67) | ALOX5APPLA2G2APLA2G1BPTGDR2CYP3A4 | |
| SCHEMBL9447692 | 0.95 | CYP3A4 (0.64) | ALOX5APPLA2G2APLA2G1BPTGDR2CYP3A4 | |
| SCHEMBL9447721 | 0.95 | PTGS2 (0.64) | ALOX5APPLA2G2APLA2G1BPTGDR2PTGS2 | |
| SCHEMBL9138282 | 0.95 | PLA2G2A (0.59) | ALOX5APPLA2G2APLA2G1BPTGDR2CYP3A4 | |
| Water SCHEMBL9146626 | 0.94 | CYP3A4 (0.63) | ALOX5APPLA2G2APLA2G1BPTGDR2CYP3A4 | |
| Water SCHEMBL9142980 | 0.94 | PTGS2 (0.63) | ALOX5APPLA2G2APLA2G1BPTGDR2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0502106-A1 | SUBSTITUTED INDOLE-, INDENE-, PYRANOINDOLE- AND TETRAHYDROCARBAZOLE- ALKANOIC ACID DERIVATIVES AS INHIBITORS OF PLA2 AND LIPOXYGENASE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-09-09 | — | — | EP | claimed |
| WO-1991006537-A2 | SUBSTITUTED INDOLE-, INDENE-, PYRANOINDOLE- AND TETRAHYDROCARBAZOLE- ALKANOIC ACID DERIVATIVES AS INHIBITORS OF PLA2 AND LIPOXYGENASE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-05-16 | — | — | WO | claimed |