Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | CYP27A1 | Q02318 | 1/20 | 0.39 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9448276 | 0.94 | GRIN2B (0.43) | NPY5RGRIN2BGRIN1MAPTUSP2 | |
| SCHEMBL9448043 | 0.82 | NPY5R (0.48) | NPY5RGRIN2BGRIN1SIGMAR1MAPT | |
| SCHEMBL9448048 | 0.82 | NPY5R (0.48) | NPY5RGRIN2BGRIN1SIGMAR1MAPT | |
| SCHEMBL9448327 | 0.81 | NPY5R (0.48) | NPY5RGRIN2BGRIN1SIGMAR1MAPT | |
| Hydrochloric Acid SCHEMBL9448267 | 0.81 | NPY5R (0.48) | NPY5RGRIN2BGRIN1SIGMAR1MAPT | |
| SCHEMBL9448182 | 0.77 | NPY5R (0.46) | NPY5RGRIN2BGRIN1MAPTLMNA | |
| SCHEMBL9448186 | 0.77 | NPY5R (0.46) | NPY5RGRIN2BGRIN1MAPTLMNA | |
| SCHEMBL9447972 | 0.75 | EED (0.46) | NPY5RMAPTLMNAHSD17B1RECQL | |
| SCHEMBL9448284 | 0.75 | CYP19A1 (0.40) | NPY5RGRIN2BGRIN1SIGMAR1HTR1A | |
| SCHEMBL9448190 | 0.74 | CYP19A1 (0.43) | NPY5RGRIN2BGRIN1SIGMAR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5248677-A | Nervous system disorders or antidepressants | ABBOTT LABORATORIES (US) | 1993-09-28 | — | — | US | disclosed |
| US-5180733-A | Antidepressants or nervous systen disorders | ABBOTT LABORATORIES (US) | 1993-01-19 | — | — | US | disclosed |