Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9448043 | 0.90 | NPY5R (0.48) | NPY5RLMNAMAPTHSD17B1RECQL | |
| SCHEMBL9448048 | 0.90 | NPY5R (0.48) | NPY5RLMNAMAPTHSD17B1RECQL | |
| Hydrochloric Acid SCHEMBL9448267 | 0.89 | NPY5R (0.48) | NPY5RLMNAMAPTHSD17B1RECQL | |
| SCHEMBL9448182 | 0.84 | NPY5R (0.46) | NPY5RLMNAMAPTHSD17B1RECQL | |
| SCHEMBL9448186 | 0.84 | NPY5R (0.46) | NPY5RLMNAMAPTHSD17B1RECQL | |
| SCHEMBL9447972 | 0.83 | EED (0.46) | NPY5RLMNAMAPTHSD17B1RECQL | |
| SCHEMBL9448102 | 0.82 | PRCP (0.51) | SIGMAR1 | |
| SCHEMBL9448423 | 0.81 | NPY5R (0.43) | NPY5RLMNAMAPTHSD17B1RECQL | |
| SCHEMBL9448134 | 0.80 | LMNA (0.41) | NPY5RLMNAMAPTHSD17B1RECQL | |
| SCHEMBL9448094 | 0.80 | LMNA (0.41) | NPY5RLMNAMAPTHSD17B1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5248677-A | Nervous system disorders or antidepressants | ABBOTT LABORATORIES (US) | 1993-09-28 | — | — | US | disclosed |
| US-5180733-A | Antidepressants or nervous systen disorders | ABBOTT LABORATORIES (US) | 1993-01-19 | — | — | US | disclosed |
| EP-0461353-A1 | Biogenic amine uptake inhibitors | ABBOTT LABORATORIES (US) | 1991-12-18 | — | — | EP | disclosed |