Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.39 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.39 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | PRKCB | P05771 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9448864 | 0.91 | GAA (0.47) | LMNASMN1; SMN2KDM4EGAAGLA | |
| SCHEMBL9448869 | 0.89 | MAPKAPK2 (0.41) | LMNASMN1; SMN2MAPKAPK2MAPKAPK5MAPKAPK3 | |
| SCHEMBL9449136 | 0.89 | LMNA (0.38) | LMNASMN1; SMN2MAPKAPK2MAPKAPK5MAPKAPK3 | |
| SCHEMBL9448900 | 0.88 | MAPKAPK2 (0.40) | LMNASMN1; SMN2MAPKAPK2MAPKAPK5MAPKAPK3 | |
| SCHEMBL9448767 | 0.85 | MCHR1 (0.50) | SMN1; SMN2MAPKAPK2MAPKAPK5MAPKAPK3KDM4E | |
| SCHEMBL9449189 | 0.83 | MCHR1 (0.40) | MAPKAPK2MAPKAPK5MAPKAPK3KDM4EMCHR1 | |
| SCHEMBL9448822 | 0.82 | KDM4E (0.47) | MAPKAPK2KDM4EGLAMCHR1ALDH1A1 | |
| SCHEMBL9448904 | 0.80 | KDM4E (0.41) | MAPKAPK2KDM4EMCHR1ALDH1A1HSD17B10 | |
| SCHEMBL9449066 | 0.80 | CYP1A2 (0.40) | GAAMCHR1HSD17B10HTR1D | |
| SCHEMBL9449046 | 0.80 | KMT2A (0.36) | MAPKAPK2KDM4EGAAGLAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5227386-A | INDOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-07-13 | — | — | US | disclosed |