Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 6/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22530050 | 0.96 | HSPB1 (0.91) | HSPB1MAPTNPSR1L3MBTL1GAA | |
| SCHEMBL29392306 | 0.96 | HSPB1 (0.91) | HSPB1MAPTNPSR1L3MBTL1GAA | |
| SCHEMBL20932230 | 0.90 | HSPB1 (0.82) | HSPB1MAPTNPSR1L3MBTL1GAA | |
| SCHEMBL11198841 | 0.86 | HSPB1 (0.75) | HSPB1MAPTNPSR1L3MBTL1GAA | |
| SCHEMBL6331907 | 0.84 | HSPB1 (0.73) | HSPB1MAPTNPSR1L3MBTL1GAA | |
| SCHEMBL10468493 | 0.84 | HSPB1 (0.73) | HSPB1MAPTNPSR1L3MBTL1GAA | |
| SCHEMBL4716681 | 0.84 | HSPB1 (0.73) | HSPB1MAPTNPSR1L3MBTL1GAA | |
| SCHEMBL10466511 | 0.84 | HSPB1 (0.73) | HSPB1MAPTNPSR1L3MBTL1GAA | |
| SCHEMBL6204892 | 0.84 | HSPB1 (0.73) | HSPB1MAPTNPSR1L3MBTL1GAA | |
| SCHEMBL177664 | 0.84 | HSPB1 (0.73) | HSPB1MAPTNPSR1L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5219863-A | Treating hypertension and congestive heat failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-15 | — | — | US | disclosed |
| EP-0487252-A1 | Quinoline and 1,5-Naphthyridine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | ZENECA LIMITED (GB) | 1992-05-27 | — | — | EP | disclosed |