Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | APLNR | P35414 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846186 | 0.88 | MAPT (0.48) | MAPTRAB9ANPC1APLNRSMN1; SMN2 | |
| SCHEMBL9846095 | 0.83 | MAPT (0.50) | MAPTRAB9ANPC1APLNRSMN1; SMN2 | |
| SCHEMBL9449230 | 0.83 | MAPT (0.50) | MAPTRAB9ANPC1APLNRSMN1; SMN2 | |
| SCHEMBL9682811 | 0.81 | HCAR2 (0.37) | MAPTRAB9ANPC1APLNRHCAR2 | |
| SCHEMBL5573693 | 0.80 | MAPT (0.54) | MAPTRAB9ANPC1APLNRSMN1; SMN2 | |
| SCHEMBL9680279 | 0.74 | TSHR (0.41) | MAPTRAB9AHCAR2CDK5CDK5R1 | |
| SCHEMBL9682115 | 0.72 | HCAR2 (0.33) | MAPTRAB9ANPC1HCAR2KDM4E | |
| SCHEMBL9846131 | 0.72 | MAPT (0.44) | MAPTRAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL9846311 | 0.72 | MAPT (0.44) | MAPTRAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL9846076 | 0.72 | MAPT (0.44) | MAPTRAB9ANPC1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5202243-A | Biosynthetic hydroxylation yields polymerase inhibitors | MERCK & CO., INC. (US) | 1993-04-13 | — | — | US | disclosed |
| US-5185251-A | Treatment of HIV and AIDS | MERCK & CO., INC. (US) | 1993-02-09 | — | — | US | disclosed |
| EP-0481802-A1 | Hydroxylated inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1992-04-22 | — | — | EP | disclosed |
| EP-0462800-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |