Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846112 | 0.92 | TP53 (0.44) | MAPTNPC1RAB9ATP53LMNA | |
| SCHEMBL9846131 | 0.92 | MAPT (0.44) | MAPTNPC1RAB9ATP53LMNA | |
| SCHEMBL9846311 | 0.90 | MAPT (0.44) | MAPTNPC1RAB9ATP53LMNA | |
| SCHEMBL9846108 | 0.83 | MAPT (0.41) | MAPTNPC1RAB9ATP53LMNA | |
| SCHEMBL9680846 | 0.72 | L3MBTL1 (0.40) | MAPTNPC1RAB9ATP53LMNA | |
| SCHEMBL9449331 | 0.72 | MAPT (0.44) | MAPTNPC1RAB9ATP53LMNA | |
| SCHEMBL9449230 | 0.70 | MAPT (0.50) | MAPTNPC1RAB9ATP53LMNA | |
| SCHEMBL9846186 | 0.69 | MAPT (0.48) | MAPTNPC1RAB9ATP53LMNA | |
| SCHEMBL9449238 | 0.69 | ATP4A (0.40) | NPC1RAB9A | |
| SCHEMBL9449235 | 0.69 | ATP4A (0.40) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462800-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |