Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | MDM4 | O15151 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31520503 | 1.00 | CASP3 (0.50) | CASP3KMT2AEPHX2MDM4TP53 | |
| SCHEMBL29398691 | 1.00 | CASP3 (0.50) | CASP3KMT2AEPHX2MDM4TP53 | |
| SCHEMBL29400883 | 0.90 | KMT2A (0.57) | CASP3KMT2AEPHX2MDM4TP53 | |
| SCHEMBL6520211 | 0.90 | KMT2A (0.57) | CASP3KMT2AEPHX2MDM4TP53 | |
| SCHEMBL25186508 | 0.88 | CASP3 (0.59) | CASP3KMT2AEPHX2MDM4TP53 | |
| SCHEMBL29400907 | 0.88 | CASP3 (0.59) | CASP3KMT2AEPHX2MDM4TP53 | |
| SCHEMBL119197 | 0.88 | CASP3 (0.59) | CASP3KMT2AEPHX2MDM4TP53 | |
| SCHEMBL30759963 | 0.88 | CASP3 (0.59) | CASP3KMT2AEPHX2MDM4TP53 | |
| SCHEMBL14265318 | 0.88 | CASP3 (0.59) | CASP3KMT2AEPHX2MDM4TP53 | |
| SCHEMBL1828815 | 0.87 | KMT2A (0.52) | CASP3KMT2AEPHX2MDM4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0531443-A4 | METHODS FOR TREATING INFLAMMATION AND COMPOUNDS AND COMPOSITIONS SUITABLE FOR USE THEREIN | — | 1993-04-21 | — | — | EP | disclosed |
| EP-0531443-A1 | METHODS FOR TREATING INFLAMMATION AND COMPOUNDS AND COMPOSITIONS SUITABLE FOR USE THEREIN | NOVA PHARMACEUTICAL CORPORATION (US) | 1993-03-17 | — | — | EP | disclosed |
| US-5079260-A | Side effect reduction; fluorene derivatives | NOVA PHARMACEUTICAL CORPORATION (US) | 1992-01-07 | — | — | US | disclosed |
| WO-1991018596-A1 | METHODS FOR TREATING INFLAMMATION AND COMPOUNDS AND COMPOSITIONS SUITABLE FOR USE THEREIN | WEITZBERG MOSHE (US) | 1991-12-12 | — | — | WO | disclosed |