Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 14/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.65 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.61 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9657563 | 1.00 | OPRK1 (0.75) | OPRK1CYP2D6OPRM1OPRD1 | |
| SCHEMBL9449823 | 1.00 | OPRK1 (0.75) | OPRK1CYP2D6OPRM1OPRD1 | |
| SCHEMBL9657727 | 1.00 | OPRK1 (0.75) | OPRK1CYP2D6OPRM1OPRD1 | |
| SCHEMBL6360245 | 1.00 | OPRK1 (0.75) | OPRK1CYP2D6OPRM1OPRD1 | |
| SCHEMBL9450167 | 1.00 | OPRK1 (0.75) | OPRK1CYP2D6OPRM1OPRD1 | |
| SCHEMBL9450172 | 1.00 | OPRK1 (0.75) | OPRK1CYP2D6OPRM1OPRD1 | |
| SCHEMBL5630756 | 0.88 | OPRK1 (0.63) | OPRK1CYP2D6OPRM1OPRD1 | |
| SCHEMBL5629605 | 0.87 | OPRK1 (0.62) | OPRK1CYP2D6OPRM1OPRD1 | |
| SCHEMBL5629262 | 0.86 | OPRK1 (1.00) | OPRK1CYP2D6OPRM1OPRD1 | |
| SCHEMBL8459482 | 0.86 | OPRK1 (1.00) | OPRK1CYP2D6OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5232978-A | 1-(2-arylethyl)-pyrrolidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-08-03 | — | — | US | disclosed |
| EP-0483580-A2 | 1-(2-Arylethyl)-pyrrolidine | MERCK PATENT GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |