Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14871996 | 0.85 | CYP2D6 (0.52) | OPRK1LMNAHDAC4HDAC1HDAC7 | |
| SCHEMBL2478440 | 0.85 | CYP2D6 (0.52) | OPRK1LMNAHDAC4HDAC1HDAC7 | |
| SCHEMBL2777368 | 0.85 | CYP2D6 (0.52) | OPRK1LMNAHDAC4HDAC1HDAC7 | |
| SCHEMBL20434116 | 0.80 | OPRK1 (0.53) | OPRK1LMNAGAAKMT2AMEN1 | |
| SCHEMBL20434134 | 0.80 | OPRK1 (0.53) | OPRK1LMNAGAAKMT2AMEN1 | |
| SCHEMBL22468482 | 0.72 | SRD5A2 (0.47) | ALDH1A1HPGD | |
| SCHEMBL8645113 | 0.72 | OPRK1 (0.44) | OPRK1LMNAHDAC4HDAC1HDAC7 | |
| SCHEMBL15359365 | 0.72 | OPRK1 (0.47) | OPRK1LMNAGAAHDAC4HDAC1 | |
| SCHEMBL11503746 | 0.72 | SRC (0.47) | OPRK1GAACYP2D6KMT2AALDH1A1 | |
| SCHEMBL12174989 | 0.72 | OPRK1 (0.47) | OPRK1LMNAGAAHDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5232978-A | 1-(2-arylethyl)-pyrrolidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-08-03 | — | — | US | disclosed |