Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 13/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 11/20 | 0.39 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9450235 | 0.72 | — | — | |
| SCHEMBL15415746 | 0.70 | PTGS1 (0.40) | KEAP1NFE2L2PTGS1PTGS2GLO1 | |
| SCHEMBL9450192 | 0.70 | ALDH1A1 (0.44) | HTT | |
| SCHEMBL2207466 | 0.68 | KEAP1 (0.47) | KEAP1NFE2L2PTGS1PTGS2GLO1 | |
| SCHEMBL14960632 | 0.68 | PTGS1 (0.67) | PTGS1PTGS2 | |
| SCHEMBL9449762 | 0.68 | ALDH1A1 (0.44) | — | |
| SCHEMBL23833571 | 0.66 | PIK3CA (0.46) | KEAP1NFE2L2PTGS1PTGS2PIK3CD | |
| SCHEMBL30094525 | 0.66 | PIK3CA (0.46) | KEAP1NFE2L2PTGS1PTGS2PIK3CD | |
| SCHEMBL16492684 | 0.66 | KEAP1 (0.41) | KEAP1NFE2L2PTGS1PTGS2GLO1 | |
| SCHEMBL2207940 | 0.65 | KEAP1 (0.48) | KEAP1NFE2L2PTGS1PTGS2GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5232978-A | 1-(2-arylethyl)-pyrrolidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-08-03 | — | — | US | disclosed |
| EP-0483580-A2 | 1-(2-Arylethyl)-pyrrolidine | MERCK PATENT GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |