Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 0.53 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL946551 | 0.89 | S1PR1 (0.53) | S1PR1S1PR4S1PR5ADORA3S1PR2 | |
| SCHEMBL945300 | 0.84 | S1PR1 (0.75) | S1PR1S1PR4S1PR5ADORA3S1PR2 | |
| SCHEMBL946705 | 0.84 | S1PR1 (0.68) | S1PR1S1PR4S1PR5ADORA3S1PR2 | |
| SCHEMBL945721 | 0.84 | MAPKAPK2 (0.56) | S1PR1 | |
| SCHEMBL951334 | 0.83 | S1PR1 (0.60) | S1PR1 | |
| SCHEMBL948110 | 0.81 | S1PR1 (0.59) | S1PR1S1PR4S1PR5ADORA3S1PR2 | |
| SCHEMBL1941774 | 0.78 | S1PR1 (0.64) | S1PR1S1PR4S1PR5ADORA3 | |
| SCHEMBL947597 | 0.77 | S1PR1 (0.55) | S1PR1S1PR4S1PR5ADORA3 | |
| SCHEMBL947568 | 0.77 | TRPV1 (0.49) | — | |
| SCHEMBL28340442 | 0.75 | S1PR1 (0.60) | S1PR1S1PR4S1PR5ADORA3S1PR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005295-A1 | MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |