Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.62 |
| ▸ | FYN | P06241 | 4/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.47 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.46 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12871321 | 0.90 | HSD17B1 (0.57) | NPC1RAB9ANLRP3FYNOPRD1 | |
| SCHEMBL17279832 | 0.88 | RAB9A (0.67) | NPC1RAB9ANLRP3FYNFGFR1 | |
| SCHEMBL10775340 | 0.84 | NPC1 (0.77) | NPC1RAB9ANLRP3FGFR1MEN1 | |
| SCHEMBL27544953 | 0.83 | NPC1 (0.71) | NPC1RAB9ANLRP3FYNHSD17B1 | |
| SCHEMBL1180816 | 0.81 | HSD17B1 (0.57) | NPC1RAB9ANLRP3FYNHSD17B1 | |
| SCHEMBL18122023 | 0.81 | RAB9A (0.58) | NPC1RAB9ANLRP3MEN1GAA | |
| SCHEMBL6263490 | 0.81 | RAB9A (0.58) | NPC1RAB9ANLRP3FGFR1MEN1 | |
| SCHEMBL181755 | 0.80 | NPC1 (0.54) | NPC1RAB9ANLRP3FGFR1MEN1 | |
| SCHEMBL18120009 | 0.77 | NPC1 (0.54) | NPC1RAB9ANLRP3OPRD1OPRM1 | |
| SCHEMBL19198665 | 0.77 | NPC1 (0.54) | NPC1RAB9ANLRP3GRM5GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5273993-A | Antiarthritic agents; osteoporosis | A. H. ROBINS COMPANY, INCORPORATED (US) | 1993-12-28 | — | — | US | disclosed |
| US-5194446-A | Antiarthritic agents | A. H. ROBINS COMPANY, INCORPORATED (US) | 1993-03-16 | — | — | US | disclosed |
| US-5192785-A | Sulfamates as antiglaucoma agents | A. H. ROBINS COMPANY, INCORPORATED (US) | 1993-03-09 | — | — | US | disclosed |
| US-5025031-A | Aryl and aryloxyalkyl sulfamate esters useful as anticonvulsants | A. H. ROBINS CO., INC. (US) | 1991-06-18 | — | — | US | disclosed |
| EP-0403185-A2 | Compounds having one or more aminosulfonyloxy radicals useful as pharmaceuticals | A.H. ROBINS COMPANY, INCORPORATED (US) | 1990-12-19 | — | — | EP | disclosed |