Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CTSE | P14091 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL945955 | 1.00 | BACE1 (0.42) | BACE1LMNAALDH1A1HPGDALOX15 | |
| SCHEMBL932692 | 1.00 | BACE1 (0.42) | BACE1LMNAALDH1A1HPGDALOX15 | |
| SCHEMBL6891601 | 0.85 | BACE1 (0.35) | BACE1LMNAALDH1A1HPGDALOX15 | |
| SCHEMBL945923 | 0.74 | ALDH1A1 (0.39) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL931327 | 0.68 | BACE1 (0.53) | BACE1SLC6A4SLC6A3SLC6A2CYP3A4 | |
| SCHEMBL931861 | 0.68 | BACE1 (0.53) | BACE1SLC6A4SLC6A3SLC6A2CYP3A4 | |
| SCHEMBL932399 | 0.68 | BACE1 (0.53) | BACE1SLC6A4SLC6A3SLC6A2CYP3A4 | |
| SCHEMBL945249 | 0.68 | CHRNA1 (0.37) | BACE1ALDH1A1HSD17B10SLC6A4SLC6A3 | |
| SCHEMBL16108921 | 0.61 | BACE1 (0.55) | BACE1LMNAALDH1A1HPGDALOX15 | |
| SCHEMBL4599181 | 0.60 | BACE1 (0.46) | BACE1TSHRSLC6A4SLC6A3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |