Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 3/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9328925 | 1.00 | TSHR (0.45) | TSHRHPGDBRD4SIGMAR1MEN1 | |
| SCHEMBL9453529 | 1.00 | TSHR (0.45) | TSHRHPGDBRD4SIGMAR1MEN1 | |
| SCHEMBL9328931 | 1.00 | TSHR (0.45) | TSHRHPGDBRD4SIGMAR1MEN1 | |
| SCHEMBL9328917 | 1.00 | TSHR (0.45) | TSHRHPGDBRD4SIGMAR1MEN1 | |
| SCHEMBL9328874 | 0.95 | SIGMAR1 (0.44) | TSHRHPGDBRD4SIGMAR1MEN1 | |
| SCHEMBL9329976 | 0.95 | SIGMAR1 (0.44) | TSHRHPGDBRD4SIGMAR1MEN1 | |
| SCHEMBL9328866 | 0.95 | SIGMAR1 (0.44) | TSHRHPGDBRD4SIGMAR1MEN1 | |
| SCHEMBL9328868 | 0.95 | SIGMAR1 (0.44) | TSHRHPGDBRD4SIGMAR1MEN1 | |
| SCHEMBL9329991 | 0.95 | SIGMAR1 (0.44) | TSHRHPGDBRD4SIGMAR1MEN1 | |
| SCHEMBL9329446 | 0.83 | CFTR (0.46) | TSHRHPGDBRD4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5234933-A | Antiflammatory agents, enzyme inhibitors | BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY AND VANDERBILT UNIVERSITY (US) | 1993-08-10 | — | — | US | disclosed |