Maleic Acid

SCHEMBL9454504

CCN(C/C=C/C#CC(C)(C)C)Cc1cccc(OCc2cc(-c3ccsc3)cs2)c1.O=C(O)/C=C\C(=O)O

nearest known ligand 0.90

Known targets — ChEMBL curated mechanism

ACE ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 BTK CACNA1C CACNA1D CACNA1F CACNA1S CCR5 CPT1B CPT2 DPP4 DRD1 DRD2 EGFR ERBB2 ERBB4 HRH1 HRH3 HTR1A HTR2A HTR2B HTR2C HTR4 JAK1 JAK2 JAK3 MPL MTOR P PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PPARG SLC6A2 SLC6A3 SLC6A4 SMO TYK2 pol

The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 1)

	gene	UniProt	supporting neighbours	confidence
▸	SQLE	Q14534	20/20	0.90

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Fumaric Acid SCHEMBL9454510	1.00	SQLE (0.90)	SQLE
SCHEMBL9454494	0.95	SQLE (1.00)	SQLE
SCHEMBL9454490	0.95	SQLE (1.00)	SQLE
Hydrochloric Acid SCHEMBL408927	0.94	SQLE (0.98)	SQLE
Hydrochloric Acid SCHEMBL408929	0.94	SQLE (0.98)	SQLE
SCHEMBL9454347	0.85	SQLE (0.81)	SQLE
SCHEMBL9454356	0.85	SQLE (0.81)	SQLE
Hydrochloric Acid SCHEMBL9052914	0.83	SQLE (0.79)	SQLE
Hydrochloric Acid SCHEMBL9052919	0.83	SQLE (0.79)	SQLE
SCHEMBL9454200	0.83	SQLE (0.78)	SQLE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-4659812-A1	DETECTION METHODS AND COMBINATION THERAPIES OF CELLS WITH EXTRACELLULAR RAS EXPRESSION	Bumm, Thomas (DE)	2025-12-10	—	—	EP	disclosed
US-5234946-A	Anticholesterol, antilipemic	BANYU PHARMACEUTICAL CO., LTD. (JP)	1993-08-10	—	—	US	disclosed