Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 1/20 | 0.70 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.47 |
| ▸ | HNF4A | P41235 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9454564 | 1.00 | POLB (0.70) | POLBNPC1RAB9AHCAR2PTGS2 | |
| SCHEMBL5527097 | 0.88 | PTGS2 (0.68) | POLBNPC1RAB9AHCAR2PTGS2 | |
| SCHEMBL5527093 | 0.88 | PTGS2 (0.68) | POLBNPC1RAB9AHCAR2PTGS2 | |
| SCHEMBL14342571 | 0.78 | PTGS2 (0.68) | POLBNPC1RAB9APTGS2DAO | |
| SCHEMBL16231708 | 0.78 | DAO (0.54) | POLBNPC1RAB9APTGS2PTPN1 | |
| SCHEMBL1793303 | 0.77 | PTGS2 (0.87) | POLBNPC1RAB9APTGS2KDM4E | |
| SCHEMBL1793300 | 0.77 | PTGS2 (0.87) | POLBNPC1RAB9APTGS2KDM4E | |
| SCHEMBL1793302 | 0.77 | PTGS2 (0.87) | POLBNPC1RAB9APTGS2KDM4E | |
| SCHEMBL14342572 | 0.77 | PTGS2 (0.87) | POLBNPC1RAB9APTGS2KDM4E | |
| SCHEMBL5599558 | 0.77 | HCAR2 (0.63) | POLBNPC1RAB9AHCAR2DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1922149-A | Pyrrole and pyrazole daao inhibitors | SEPRACOR INC (US) | 2007-02-28 | — | — | CN | claimed |
| CN-1922149-A | Pyrrole and pyrazole daao inhibitors | SEPRACOR INC (US) | 2007-02-28 | — | — | CN | disclosed |
| US-5234946-A | Anticholesterol, antilipemic | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1993-08-10 | — | — | US | disclosed |
| EP-0318860-B1 | SUBSTITUTED ALKYLAMINE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1993-06-16 | — | — | EP | disclosed |
| EP-0318860-A2 | Substituted alkylamine derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1989-06-07 | — | — | EP | disclosed |