Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1793300 | 0.90 | PTGS2 (0.87) | PTGS2KDM4EHPGDLMNACYP1A2 | |
| SCHEMBL1793302 | 0.90 | PTGS2 (0.87) | PTGS2KDM4EHPGDLMNACYP1A2 | |
| SCHEMBL1793303 | 0.90 | PTGS2 (0.87) | PTGS2KDM4EHPGDLMNACYP1A2 | |
| SCHEMBL14342572 | 0.90 | PTGS2 (0.87) | PTGS2KDM4EHPGDLMNACYP1A2 | |
| SCHEMBL17068289 | 0.89 | PTGS2 (0.56) | PTGS2KDM4EHPGDLMNACYP1A2 | |
| SCHEMBL27766349 | 0.81 | KDM4E (0.54) | PTGS2KDM4EHPGDLMNACYP1A2 | |
| SCHEMBL1790052 | 0.79 | APP (0.88) | PTGS2MAPTNFKB1APPALOX5 | |
| SCHEMBL1790054 | 0.79 | APP (0.88) | PTGS2MAPTNFKB1APPALOX5 | |
| SCHEMBL27773488 | 0.78 | POLB (0.50) | PTGS2KDM4EHPGDLMNACYP1A2 | |
| SCHEMBL29799041 | 0.78 | PTGS2 (0.65) | PTGS2KDM4ELMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022186362-A1 | METHOD FOR PRODUCING PYRAZOLE COMPOUND | 白鳥製薬株式会社 | 2022-09-09 | — | — | WO | disclosed |
| US-8710038-B2 | Pyrazole kinase modulators and methods of use | EXELIXIS, INC. (US) | 2014-04-29 | — | — | US | disclosed |
| US-20070293507-A1 | Pyrazole Kinase Modulators And Methods Of Use | EXELIXIS, INC. (US) | 2007-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293507-A1 | Pyrazole Kinase Modulators And Methods Of Use | MAP3K1, MAP3K3, MAP3K5 | PTGS2 768/4885KDM4E 1090/4885HPGD 1237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.