Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP14 | P54578 | 3/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | ITK | Q08881 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2014862 | 0.85 | MIF (0.40) | F2TSHRHSD17B10KDM4EALDH1A1 | |
| SCHEMBL10532632 | 0.68 | PPARA (0.47) | CYP1A2GRM5CYP11B2 | |
| SCHEMBL22070895 | 0.68 | CYP11B1 (0.42) | MAPTL3MBTL1KDM4EALDH1A1HPGD | |
| SCHEMBL12320236 | 0.68 | S1PR1 (0.46) | S1PR1ALDH1A1GAAMAPK1 | |
| SCHEMBL933742 | 0.67 | ALDH1A1 (0.42) | USP14MAPTALDH1A1GAAMAPK1 | |
| SCHEMBL9588938 | 0.66 | FFAR4 (0.40) | S1PR1MAPTTSHRHSD17B10KDM4E | |
| SCHEMBL7753345 | 0.66 | USP14 (0.52) | USP14MAPTL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL950210 | 0.65 | S1PR1 (0.58) | S1PR1 | |
| SCHEMBL2018070 | 0.65 | GAA (0.37) | S1PR1MAPTTSHRHSD17B10KDM4E | |
| SCHEMBL2470686 | 0.64 | MAPT (0.48) | MAPTTSHRHSD17B10KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005290-A1 | DISUBSTITUTED OXADIAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |