Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.58 |
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.56 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.56 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.56 |
| ▸ | PHF8 | Q9UPP1 | 5/20 | 0.48 |
| ▸ | KDM2A | Q9Y2K7 | 5/20 | 0.48 |
| ▸ | KDM5C | P41229 | 4/20 | 0.48 |
| ▸ | KDM6B | O15054 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL27781769 | 0.88 | LMNA (0.61) | TSHRALDH1A1LMNAHSD17B10TDP1 | |
| Adipic Acid SCHEMBL9342268 | 0.88 | LMNA (0.61) | TSHRALDH1A1LMNAHSD17B10TDP1 | |
| SCHEMBL1396840 | 0.86 | EGLN1 (0.50) | TSHRALDH1A1LMNASLC15A2EGLN1 | |
| Butyric Acid SCHEMBL4847284 | 0.86 | FFAR3 (0.68) | TSHRALDH1A1LMNASLC15A2FFAR3 | |
| Propionic Acid SCHEMBL9084811 | 0.84 | ALDH1A1 (0.67) | TSHRALDH1A1LMNASLC15A2FFAR3 | |
| SCHEMBL8475243 | 0.84 | EGLN1 (0.48) | TSHRALDH1A1LMNASLC15A2EGLN1 | |
| SCHEMBL27750933 | 0.84 | EGLN1 (0.48) | TSHRALDH1A1LMNASLC15A2EGLN1 | |
| Ammonia Solution, Strong SCHEMBL16395684 | 0.84 | EGLN1 (0.48) | TSHRALDH1A1LMNASLC15A2EGLN1 | |
| Hydrogen Peroxide SCHEMBL15610564 | 0.83 | — | — | |
| Hydrogen Peroxide SCHEMBL28219767 | 0.83 | TSHR (0.91) | TSHRALDH1A1LMNAEGLN1FFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5223242-A | Negatively charged specific affinity reagents | THE GENERAL HOSPITAL CORPORATION (US) | 1993-06-29 | — | — | US | disclosed |