Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MMP2 | P08253 | 5/20 | 0.36 |
| ▸ | MMP3 | P08254 | 5/20 | 0.36 |
| ▸ | MMP1 | P03956 | 3/20 | 0.36 |
| ▸ | MMP7 | P09237 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | GMNN | O75496 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9457371 | 1.00 | GPR84 (0.41) | GPR84MEN1KMT2AMMP2MMP3 | |
| SCHEMBL9457368 | 1.00 | GPR84 (0.41) | GPR84MEN1KMT2AMMP2MMP3 | |
| SCHEMBL9457193 | 1.00 | GPR84 (0.41) | GPR84MEN1KMT2AMMP2MMP3 | |
| SCHEMBL9649923 | 1.00 | GPR84 (0.41) | GPR84MEN1KMT2AMMP2MMP3 | |
| SCHEMBL30861816 | 0.95 | MEN1 (0.36) | GPR84MEN1KMT2AMMP1MMP7 | |
| SCHEMBL9457388 | 0.93 | FFAR1 (0.39) | KMT2AMMP2CYP1A2GMNNLMNA | |
| SCHEMBL9457366 | 0.93 | FFAR1 (0.39) | KMT2AMMP2CYP1A2GMNNLMNA | |
| SCHEMBL9457391 | 0.93 | FFAR1 (0.39) | KMT2AMMP2CYP1A2GMNNLMNA | |
| SCHEMBL9457394 | 0.93 | FFAR1 (0.39) | KMT2AMMP2CYP1A2GMNNLMNA | |
| SCHEMBL9457402 | 0.93 | FFAR1 (0.39) | KMT2AMMP2CYP1A2GMNNLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5246960-A | Used to treat obesity, hyperlipaemia, atherosclerosis and arteriosclerosis | HOFFMANN-LA ROCHE INC. (US) | 1993-09-21 | — | — | US | disclosed |
| US-5175186-A | Inhibits pancreas lepase and useful agent in treatment of obesity, hyperlipemia, atherosclerosis and arteriosclerosis | HOFFMANN-LA ROCHE INC. (US) | 1992-12-29 | — | — | US | disclosed |
| US-4983746-A | Oxetanones and process for their production | HOFFMANN-LA ROCHE INC. (US) | 1991-01-08 | — | — | US | disclosed |
| US-4931463-A | PANCREAS LIPASE INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1990-06-05 | — | — | US | disclosed |