Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | TERT | O14746 | 3/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.39 |
| ▸ | PPARG | P37231 | 3/20 | 0.39 |
| ▸ | PPARD | Q03181 | 3/20 | 0.39 |
| ▸ | PPARA | Q07869 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | FABP4 | P15090 | 2/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9457372 | 1.00 | FFAR1 (0.39) | FFAR1FFAR4TERTPTPN1PPARG | |
| SCHEMBL9457394 | 1.00 | FFAR1 (0.39) | FFAR1FFAR4TERTPTPN1PPARG | |
| SCHEMBL9457382 | 1.00 | FFAR1 (0.39) | FFAR1FFAR4TERTPTPN1PPARG | |
| SCHEMBL9457388 | 1.00 | FFAR1 (0.39) | FFAR1FFAR4TERTPTPN1PPARG | |
| SCHEMBL9457402 | 1.00 | FFAR1 (0.39) | FFAR1FFAR4TERTPTPN1PPARG | |
| SCHEMBL9457391 | 1.00 | FFAR1 (0.39) | FFAR1FFAR4TERTPTPN1PPARG | |
| SCHEMBL9457085 | 0.97 | ALDH1A1 (0.42) | FFAR1FFAR4PPARGPPARDPPARA | |
| SCHEMBL9457076 | 0.97 | ALDH1A1 (0.42) | FFAR1FFAR4PPARGPPARDPPARA | |
| SCHEMBL9457193 | 0.93 | GPR84 (0.41) | MAPTBLMGMNNLMNACYP1A2 | |
| SCHEMBL9457380 | 0.93 | GPR84 (0.41) | MAPTBLMGMNNLMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5246960-A | Used to treat obesity, hyperlipaemia, atherosclerosis and arteriosclerosis | HOFFMANN-LA ROCHE INC. (US) | 1993-09-21 | — | — | US | disclosed |
| US-5175186-A | Inhibits pancreas lepase and useful agent in treatment of obesity, hyperlipemia, atherosclerosis and arteriosclerosis | HOFFMANN-LA ROCHE INC. (US) | 1992-12-29 | — | — | US | disclosed |
| US-4931463-A | PANCREAS LIPASE INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1990-06-05 | — | — | US | disclosed |