Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | MAP2 | P11137 | 2/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | PLCG1 | P19174 | 2/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9670303 | 0.84 | ALDH1A1 (0.52) | KDM4EALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL6535836 | 0.75 | GPR17 (0.37) | KDM4EALDH1A1HPGDMAP2GPR35 | |
| SCHEMBL3091466 | 0.74 | KDM4E (1.00) | KDM4EALDH1A1HPGDMAP2FOLH1 | |
| SCHEMBL9816507 | 0.74 | KDM4E (0.79) | KDM4EALDH1A1HPGDMAP2GAA | |
| Hydrochloric Acid SCHEMBL5203951 | 0.73 | KDM4E (0.96) | KDM4EALDH1A1HPGDMAP2FOLH1 | |
| SCHEMBL1613575 | 0.69 | KDM4E (0.61) | KDM4EALDH1A1HPGDMAP2FOLH1 | |
| SCHEMBL30220650 | 0.69 | KDM4E (0.61) | KDM4EALDH1A1HPGDMAP2FOLH1 | |
| SCHEMBL7591935 | 0.68 | KDM4E (0.79) | KDM4EALDH1A1HPGDMAP2GAA | |
| SCHEMBL9441674 | 0.68 | KDM4E (0.79) | KDM4EALDH1A1HPGDMAP2GAA | |
| SCHEMBL7594894 | 0.67 | KDM4E (0.71) | KDM4EALDH1A1HPGDMAP2FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5225421-A | Leukotriene antagonists; cytoprotective agents | MERCK FROSST CANADA, INC. (CA) | 1993-07-06 | — | — | US | disclosed |
| US-5081138-A | Antiasthmatic, antiallergic, antiinflammatory and cytoprotective agents | MERCK FROSST CANADA, INC. (CA) | 1992-01-14 | — | — | US | disclosed |