Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR17 | Q13304 | 5/20 | 0.37 |
| ▸ | MAP2 | P11137 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | MDM4 | O15151 | 2/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | FBP1 | P09467 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9457645 | 0.75 | KDM4E (0.57) | MAP2GPR35KDM4EALDH1A1HPGD | |
| SCHEMBL7694143 | 0.64 | MAPT (0.49) | TP53KDM4EALDH1A1 | |
| SCHEMBL7074273 | 0.62 | MDM2 (0.40) | GPR17MDM2MCL1 | |
| SCHEMBL8647087 | 0.62 | NPSR1 (0.40) | HRH1KDM4EALDH1A1 | |
| SCHEMBL7698766 | 0.62 | ALDH1A1 (0.38) | HRH1KDM4EALDH1A1 | |
| SCHEMBL8543287 | 0.61 | MAP2 (0.42) | MAP2KDM4EALDH1A1HPGD | |
| SCHEMBL5778905 | 0.61 | GPR35 (0.49) | GPR17MAP2GPR35KDM4EALDH1A1 | |
| SCHEMBL9816507 | 0.60 | KDM4E (0.79) | MAP2GPR35MDM4MDM2KDM4E | |
| SCHEMBL7463695 | 0.60 | SLC6A2 (0.41) | GPR17GRIN1MCL1 | |
| SCHEMBL5214867 | 0.59 | ALOX5 (0.47) | TP53ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1284728-A4 | PHARMACEUTICALS FOR TREATING OBESITY | MERCK & CO INC (US) | 2004-05-19 | — | — | EP | disclosed |
| EP-1284728-A1 | PHARMACEUTICALS FOR TREATING OBESITY | Merck & Co., Inc. (US) | 2003-02-26 | — | — | EP | disclosed |
| WO-2001030343-A1 | PHARMACEUTICALS FOR TREATING OBESITY | MERCK & CO., INC. (US) | 2001-05-03 | — | — | WO | disclosed |