Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.44 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9035226 | 1.00 | HTR1A (0.44) | HTR1AGNAI3HTR2CHTR2BHTR2A | |
| SCHEMBL9458029 | 1.00 | HTR1A (0.44) | HTR1AGNAI3HTR2CHTR2BHTR2A | |
| SCHEMBL9035221 | 1.00 | HTR1A (0.44) | HTR1AGNAI3HTR2CHTR2BHTR2A | |
| Hydrochloric Acid SCHEMBL9035512 | 0.99 | HTR1A (0.43) | HTR1AGNAI3HTR2CHTR2BHTR2A | |
| Hydrochloric Acid SCHEMBL9457774 | 0.99 | HTR1A (0.43) | HTR1AGNAI3HTR2CHTR2BHTR2A | |
| Hydrochloric Acid SCHEMBL9035515 | 0.99 | HTR1A (0.43) | HTR1AGNAI3HTR2CHTR2BHTR2A | |
| Hydrochloric Acid SCHEMBL9035522 | 0.99 | HTR1A (0.43) | HTR1AGNAI3HTR2CHTR2BHTR2A | |
| SCHEMBL7844867 | 0.77 | HTR2C (0.38) | HTR1AGNAI3HTR2C | |
| SCHEMBL7844871 | 0.77 | HTR2C (0.38) | HTR1AGNAI3HTR2C | |
| SCHEMBL8139163 | 0.75 | HTR1A (0.49) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422134-A1 | 5-HT SELECTIVE AGENTS. | ABBOTT LAB (US) | 1991-04-17 | — | — | EP | claimed |
| WO-1990006927-A1 | 5-HT SELECTIVE AGENTS | ABBOTT LABORATORIES (US) | 1990-06-28 | — | — | WO | claimed |
| US-5244888-A | Hexahydroindenopyrroles and hexahydrobenzisoindoles | ABBOTT LABORATORIES (US) | 1993-09-14 | — | — | US | disclosed |
| US-5049564-A | Hypotensive, 5-hydroxytryptamine | ABBOTT LABORATORIES (US) | 1991-09-17 | — | — | US | disclosed |
| EP-0422134-A1 | 5-HT SELECTIVE AGENTS. | ABBOTT LAB (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1990006927-A1 | 5-HT SELECTIVE AGENTS | ABBOTT LABORATORIES (US) | 1990-06-28 | — | — | WO | disclosed |