Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.52 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9458396 | 0.99 | HTR1A (0.51) | HTR1ADRD2ADRA1BADRA1DADRA1A | |
| SCHEMBL9458072 | 0.98 | HTR1A (0.54) | HTR1ADRD2ADRA1BADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL9458505 | 0.97 | HTR1A (0.53) | HTR1ADRD2ADRA1BADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL9458352 | 0.97 | HTR1A (0.53) | HTR1ADRD2ADRA1BADRA1DADRA1A | |
| SCHEMBL9037672 | 0.93 | HTR1A (0.56) | HTR1ADRD2ADRA1BADRA1DADRA1A | |
| SCHEMBL9034117 | 0.91 | HTR1A (0.58) | HTR1ADRD2ADRA1BADRA1DADRA1A | |
| SCHEMBL9035223 | 0.90 | HTR1A (0.57) | HTR1ADRD2ADRA1BADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL9043516 | 0.90 | HTR1A (0.57) | HTR1ADRD2ADRA1BADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL9036002 | 0.89 | HTR1A (0.56) | HTR1ADRD2ADRA1BADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL9035153 | 0.85 | HTR1A (0.57) | HTR1ADRD2ADRA1BADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422134-A1 | 5-HT SELECTIVE AGENTS. | ABBOTT LAB (US) | 1991-04-17 | — | — | EP | claimed |
| WO-1990006927-A1 | 5-HT SELECTIVE AGENTS | ABBOTT LABORATORIES (US) | 1990-06-28 | — | — | WO | claimed |
| US-5244888-A | Hexahydroindenopyrroles and hexahydrobenzisoindoles | ABBOTT LABORATORIES (US) | 1993-09-14 | — | — | US | disclosed |
| US-5049564-A | Hypotensive, 5-hydroxytryptamine | ABBOTT LABORATORIES (US) | 1991-09-17 | — | — | US | disclosed |
| EP-0422134-A1 | 5-HT SELECTIVE AGENTS. | ABBOTT LAB (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1990006927-A1 | 5-HT SELECTIVE AGENTS | ABBOTT LABORATORIES (US) | 1990-06-28 | — | — | WO | disclosed |