Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7492024 | 0.86 | FFAR1 (0.55) | FFAR1RAB9AL3MBTL1NPC1SMN1; SMN2 | |
| SCHEMBL6764561 | 0.84 | FFAR1 (0.61) | FFAR1RAB9AL3MBTL1NPC1SMN1; SMN2 | |
| SCHEMBL9361081 | 0.83 | ANPEP (0.56) | SMN1; SMN2LMNAALDH1A1KDM4EMAPT | |
| SCHEMBL28897181 | 0.81 | CYP1A2 (0.59) | RAB9AL3MBTL1NPC1SMN1; SMN2LMNA | |
| SCHEMBL10967471 | 0.80 | FFAR1 (0.67) | FFAR1L3MBTL1NPC1SMN1; SMN2LMNA | |
| SCHEMBL9471879 | 0.80 | RAB9A (0.57) | RAB9AL3MBTL1NPC1SMN1; SMN2LMNA | |
| SCHEMBL11218066 | 0.78 | ALDH1A1 (0.66) | RAB9AL3MBTL1NPC1SMN1; SMN2LMNA | |
| SCHEMBL9179407 | 0.78 | FFAR1 (0.74) | FFAR1RAB9AL3MBTL1NPC1SMN1; SMN2 | |
| SCHEMBL9457455 | 0.77 | FFAR1 (0.45) | FFAR1RAB9AL3MBTL1NPC1SMN1; SMN2 | |
| SCHEMBL9472487 | 0.77 | ACKR3 (0.57) | RAB9AL3MBTL1NPC1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5225421-A | Leukotriene antagonists; cytoprotective agents | MERCK FROSST CANADA, INC. (CA) | 1993-07-06 | — | — | US | disclosed |
| EP-0275667-B1 | 3-HETERO-SUBSTITUTED-N-BENZYL-INDOLES | MERCK FROSST CANADA INC. (CA) | 1992-03-18 | — | — | EP | disclosed |
| US-5081138-A | Antiasthmatic, antiallergic, antiinflammatory and cytoprotective agents | MERCK FROSST CANADA, INC. (CA) | 1992-01-14 | — | — | US | disclosed |
| EP-0275667-A1 | 3-hetero-substituted-N-benzyl-indoles | MERCK FROSST CANADA INC. (CA) | 1988-07-27 | — | — | EP | disclosed |
| EP-0063323-B1 | 5-SUBSTITUTED 4-OXO-PGI1 DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1985-10-30 | — | — | EP | disclosed |
| EP-0063338-B1 | 4-OXO PGI2 DERIVATIVES, METHOD FOR THEIR PREPARATION AND THEIR THERAPEUTICAL COMPOSITIONS | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1985-02-13 | — | — | EP | disclosed |
| US-4438132-A | 4-Oxo-PGI2 compounds, their use in inhibition of thrombii and their production | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1984-03-20 | — | — | US | disclosed |
| EP-0063323-A1 | 5-Substituted 4-oxo-PGI1 derivatives, their preparation and pharmaceutical compositions | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1982-10-27 | — | — | EP | disclosed |
| EP-0063338-A1 | 4-Oxo PGI2 derivatives, method for their preparation and their therapeutical compositions | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1982-10-27 | — | — | EP | disclosed |