Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL947881 | 0.90 | HSP90AA1 (0.48) | HSP90AA1HSD17B10NR3C2HDAC1GAA | |
| SCHEMBL1219625 | 0.90 | HSP90AA1 (0.51) | HSP90AA1HSD17B10SMN1; SMN2NR3C2PDE10A | |
| SCHEMBL945051 | 0.90 | HSP90AA1 (0.51) | HSP90AA1NR3C2HDAC1PDE11A | |
| SCHEMBL1218546 | 0.87 | HSP90AA1 (0.49) | HSP90AA1SMN1; SMN2NR3C2SCN9AHDAC1 | |
| SCHEMBL1219470 | 0.86 | HSP90AA1 (0.52) | HSP90AA1HSD17B10SMN1; SMN2NR3C2PDE10A | |
| SCHEMBL1216909 | 0.86 | HSP90AA1 (0.53) | HSP90AA1HSD17B10SMN1; SMN2NR3C2PDE10A | |
| SCHEMBL1219682 | 0.86 | HSP90AA1 (0.53) | HSP90AA1SMN1; SMN2NR3C2PDE10AKMT2A | |
| SCHEMBL1219427 | 0.85 | HSP90AA1 (0.49) | HSP90AA1HSD17B10SMN1; SMN2NR3C2PDE10A | |
| SCHEMBL1218495 | 0.85 | HSP90AA1 (0.49) | HSP90AA1HSD17B10SMN1; SMN2NR3C2PDE10A | |
| SCHEMBL1219638 | 0.84 | HSP90AA1 (0.52) | HSP90AA1SMN1; SMN2NR3C2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7906657-B2 | 1,5-diphenylpyrazoles II as HSP90 inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2011-03-15 | — | — | US | claimed |
| US-20090325974-A1 | 1,5-DIPHENYLPYRAZOLES II AS HSP90 INHIBITORS | MERCK PATENT GESELLSCHAFT (DE) | 2009-12-31 | — | — | US | claimed |
| US-7906657-B2 | 1,5-diphenylpyrazoles II as HSP90 inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2011-03-15 | — | — | US | disclosed |
| US-20110028485-A1 | 1,5-DIPHENYLPYRAZOLES II AS HSP90 INHIBITORS | EGGENWEILER HANS-MICHAEL | 2011-02-03 | — | — | US | disclosed |
| US-20110003691-A1 | Substituted Pyrazinylmethyl Sulfonamides For Use As Fungicides | BASF SE (DE) | 2011-01-06 | — | — | US | disclosed |
| EP-2265592-A1 | SUBSTITUTED PYRAZ INYLMETHYL SULFONAMIDES FOR USE AS. FUNGICIDES | BASF SE (DE) | 2010-12-29 | — | — | EP | disclosed |
| US-20090325974-A1 | 1,5-DIPHENYLPYRAZOLES II AS HSP90 INHIBITORS | MERCK PATENT GESELLSCHAFT (DE) | 2009-12-31 | — | — | US | disclosed |
| WO-2009112523-A1 | SUBSTITUTED PYRAZ INYLMETHYL SULFONAMIDES FOR USE AS. FUNGICIDES | BASF SE (DE) | 2009-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325974-A1 | 1,5-DIPHENYLPYRAZOLES II AS HSP90 INHIBITORS | HSP90AB1, HSP90AA1, HSP90AB2P | HSP90AA1 2/4885HSD17B10 2088/4885SMN1; SMN2 2955/4885 |
| US-20110003691-A1 | Substituted Pyrazinylmethyl Sulfonamides For Use As Fungicides | PRXL2A, ARSA, PADI1 | HSP90AA1 1862/4885HSD17B10 3878/4885SMN1; SMN2 3339/4885 |
| US-20110028485-A1 | 1,5-DIPHENYLPYRAZOLES II AS HSP90 INHIBITORS | HSP90AB1, HSP90AA1, HSP90AB2P | HSP90AA1 2/4885HSD17B10 2088/4885SMN1; SMN2 2955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.