Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6628801 | 0.80 | CHRNA7 (0.66) | CHRNA7 | |
| SCHEMBL9459255 | 0.78 | CHRNA7 (0.53) | CHRNA7 | |
| SCHEMBL9431069 | 0.77 | CHRNA7 (0.67) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL3217359 | 0.72 | CHRNA7 (1.00) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL9430901 | 0.71 | CHRNB2 (0.49) | CHRNA7 | |
| SCHEMBL9494092 | 0.69 | CHRNA7 (0.56) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL9678555 | 0.69 | CHRNA7 (0.56) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL11300641 | 0.69 | CHRNA7 (0.67) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL9459439 | 0.69 | CHRM2 (0.48) | CHRNA7CHRM2CHRM1 | |
| SCHEMBL8935429 | 0.69 | CHRM2 (0.54) | CHRNA7CHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0327155-A2 | Pyrazines, pyrimidines and pyridazines, useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-08-09 | — | — | EP | claimed |
| US-5260293-A | Simulate central muscarinic acetlycholine receptors | MERCK SHARP & DOHME LIMITED (GB) | 1993-11-09 | — | — | US | disclosed |
| EP-0327155-A2 | Pyrazines, pyrimidines and pyridazines, useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-08-09 | — | — | EP | disclosed |