Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GCGR | P47871 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9153169 | 1.00 | KDM4E (0.43) | KDM4EPOLBSMN1; SMN2MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL9152829 | 0.89 | PPARG (0.41) | MAPTKMT2AMEN1RAB9AALDH1A1 | |
| Hydrochloric Acid SCHEMBL9458906 | 0.82 | BCHE (0.49) | KDM4EPOLBSMN1; SMN2MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL9147758 | 0.82 | BCHE (0.49) | KDM4EPOLBSMN1; SMN2MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL9155429 | 0.80 | KDM4E (0.43) | KDM4EPOLBSMN1; SMN2MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL9459091 | 0.80 | KDM4E (0.43) | KDM4EPOLBSMN1; SMN2MAPTKMT2A | |
| SCHEMBL9151784 | 0.79 | KDM4E (0.44) | KDM4EPOLBSMN1; SMN2MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL9153038 | 0.74 | KMT2A (0.41) | KDM4EPOLBSMN1; SMN2MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL9152104 | 0.73 | POLB (0.38) | POLBSMN1; SMN2MAPTKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL9148122 | 0.71 | XDH (0.60) | KDM4ESMN1; SMN2MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5206371-A | Acetylcholinesterase inhibitor | GEORGIA TECH RESEARCH CORPORATION (US) | 1993-04-27 | — | — | US | disclosed |
| US-5180831-A | Acetylcholinesterase Inhibitors | GEORGIA TECH RESEARCH CORPORATION (US) | 1993-01-19 | — | — | US | disclosed |