(R/R)Befloxatone

(R/R)Befloxatone

SCHEMBL9463277

COC[C@@H]1CN(c2ccc(OCC[C@@H](O)C(F)(F)F)cc2)C(=O)O1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 10/20 0.53
MAOB P27338 5/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
(R/R)Befloxatone SCHEMBL9482918 1.00 GRM2 (0.53) GRM2MAOB
Befloxatone SCHEMBL464941 1.00 GRM2 (0.53) GRM2MAOB
(R/R)Befloxatone SCHEMBL9463614 1.00 GRM2 (0.53) GRM2MAOB
(R/R)Befloxatone SCHEMBL6455164 1.00 GRM2 (0.53) GRM2MAOB
(R/R)Befloxatone SCHEMBL3699065 1.00 GRM2 (0.53) GRM2MAOB
(R/R)Befloxatone SCHEMBL9462907 1.00 GRM2 (0.53) GRM2MAOB
(R/R)Befloxatone SCHEMBL9463708 1.00 GRM2 (0.53) GRM2MAOB
SCHEMBL9484172 0.93 GRM2 (0.52) GRM2MAOB
SCHEMBL9484176 0.93 GRM2 (0.52) GRM2MAOB
SCHEMBL9465260 0.90 GRM2 (0.51) GRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8394813-B2 Active agent delivery systems and methods for protecting and administering active agents SHIRE LLC (US) 2013-03-12 US disclosed
US-20090306228-A1 ACTIVE AGENT DELIVERY SYSTEMS AND METHODS FOR PROTECTING AND ADMINISTERING ACTIVE AGENTS SHIRE LLC (US) 2009-12-10 US disclosed
US-20090253792-A1 ACTIVE AGENT DELIVERY SYSTEMS AND METHODS FOR PROTECTING AND ADMINISTERING ACTIVE AGENTS SHIRE LLC (US) 2009-10-08 US disclosed
US-7427600-B2 Active agent delivery systems and methods for protecting and administering active agents SHIRE LLC (US) 2008-09-23 US disclosed
US-5264443-A Psychotropic drugs, antidepressants and anxiolytic agents DELALANDE S.A. (FR) 1993-11-23 US disclosed
US-5196543-A Antidepressants, tranquilizers DELALANDE S.A. (FR) 1993-03-23 US disclosed
US-5036091-A Psychotropic drugs DELALANDE S.A. (FR) 1991-07-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090253792-A1 ACTIVE AGENT DELIVERY SYSTEMS AND METHODS FOR PROTECTING AND ADMINISTERING ACTIVE AGENTS HDGF, CTSA, IAPP GRM2 3310/4885MAOB 2570/4885
US-20090306228-A1 ACTIVE AGENT DELIVERY SYSTEMS AND METHODS FOR PROTECTING AND ADMINISTERING ACTIVE AGENTS HDGF, CTSA, IAPP GRM2 3310/4885MAOB 2570/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.