(R/R)Befloxatone

(R/R)Befloxatone

SCHEMBL3699065

COCC1CN(c2ccc(OCCC(O)C(F)(F)F)cc2)C(=O)O1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 10/20 0.53
MAOB P27338 5/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
(R/R)Befloxatone SCHEMBL9482918 1.00 GRM2 (0.53) GRM2MAOB
Befloxatone SCHEMBL464941 1.00 GRM2 (0.53) GRM2MAOB
(R/R)Befloxatone SCHEMBL9463277 1.00 GRM2 (0.53) GRM2MAOB
(R/R)Befloxatone SCHEMBL9463614 1.00 GRM2 (0.53) GRM2MAOB
(R/R)Befloxatone SCHEMBL6455164 1.00 GRM2 (0.53) GRM2MAOB
(R/R)Befloxatone SCHEMBL9462907 1.00 GRM2 (0.53) GRM2MAOB
(R/R)Befloxatone SCHEMBL9463708 1.00 GRM2 (0.53) GRM2MAOB
SCHEMBL9484172 0.93 GRM2 (0.52) GRM2MAOB
SCHEMBL9484176 0.93 GRM2 (0.52) GRM2MAOB
SCHEMBL9465260 0.90 GRM2 (0.51) GRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9694014-B2 Treatment of muscular dystrophies and associated conditions by administration of monoamine oxidase inhibitors UNIVERSITA DEGLI STUDI DI PADOVA (IT) 2017-07-04 US disclosed
US-20150290201-A1 TREATMENT OF MUSCULAR DYSTROPHIES AND ASSOCIATED CONDITIONS BY ADMINISTRATION OF MONOAMINE OXIDASE INHIBITORS UNIV PADOVA (IT) 2015-10-15 US disclosed
US-8487008-B2 Treatment of muscular dystrophies and associated conditions by administration of monoamine oxidase inhibitors UNIVERSITA DEGLI STUDI DI PADOVA (IT) 2013-07-16 US disclosed
US-20130142821-A1 Hapten-Carrier Conjugates and Uses Thereof CYTOS BIOTECHNOLOGY AG (CH) 2013-06-06 US disclosed
US-20120329800-A1 TREATMENT OF MUSCULAR DYSTROPHIES AND ASSOCIATED CONDITIONS BY ADMINISTRATION OF MONOAMINE OXIDASE INHIBITORS UNIVERSITA' DEGLI STUDI DI PADOVA, (UNIVERSITY OF PADUA) 2012-12-27 US disclosed
US-8187607-B2 Hapten-carrier conjugates and uses thereof CYTOS BIOTECHNOLOGY AG (CH) 2012-05-29 US disclosed
EP-2392345-A2 Hapten-carrier conjugates comprising virus like particles and uses thereof Cytos Biotechnology AG (CH) 2011-12-07 EP disclosed
US-20100129395-A1 Hapten-carrier conjugates and uses thereof CYTOS BIOTECHNOLOGY AG (CH) 2010-05-27 US disclosed
US-7452541-B2 Hapten-carrier conjugates and uses thereof CYTOS BIOTECHNOLOGY AG (CH) 2008-11-18 US disclosed
US-20050281845-A1 Hapten-carrier conjugates and uses thereof CYTOS BIOTECHNOLOGY AG (CH) 2005-12-22 US disclosed
US-6932971-B2 Hapten-carrier conjugates and uses thereof CYTOS BIOTECHNOLOGY AG (CH) 2005-08-23 US disclosed
EP-1523334-A2 HAPTEN-CARRIER CONJUGATES AND USES THEREOF Cytos Biotechnology AG (CH) 2005-04-20 EP disclosed
EP-1307182-B1 PHARMACEUTICAL COMPOSITION FOR TRANSDERMAL DELIVERY OF BEFLOXATONE SANOFI AVENTIS (FR) 2005-03-30 EP disclosed
US-20040059094-A1 Hapten-carrier conjugates and uses thereof CYTOS BIOTECHNOLOGY AG (CH) 2004-03-25 US disclosed
WO-2004009116-A2 HAPTEN-CARRIER CONJUGATES COMPRISING VIRUS LIKE PARTICLES AND USES THEREOF CYTOS BIOTECHNOLOGY AG (CH) 2004-01-29 WO disclosed
EP-0736606-B1 Process for the enzymatic preparation of intermediates for the synthesis of befloxatone SANOFI SYNTHELABO (FR) 2002-01-02 EP disclosed
EP-0736606-A1 Process for the enzymatic preparation of intermediates for the synthesis of befloxatone SYNTHELABO (FR) 1996-10-09 EP disclosed
US-5264443-A Psychotropic drugs, antidepressants and anxiolytic agents DELALANDE S.A. (FR) 1993-11-23 US disclosed
US-5196543-A Antidepressants, tranquilizers DELALANDE S.A. (FR) 1993-03-23 US disclosed
US-5036091-A Psychotropic drugs DELALANDE S.A. (FR) 1991-07-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150290201-A1 TREATMENT OF MUSCULAR DYSTROPHIES AND ASSOCIATED CONDITIONS BY ADMINISTRATION OF MONOAMINE OXIDASE INHIBITORS MAOA, MAOB, MUSK GRM2 1157/4885MAOB 2/4885
US-20120329800-A1 TREATMENT OF MUSCULAR DYSTROPHIES AND ASSOCIATED CONDITIONS BY ADMINISTRATION OF MONOAMINE OXIDASE INHIBITORS MAOA, MAOB, MUSK GRM2 1157/4885MAOB 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.