Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13444455 | 0.91 | MAPT (0.53) | KCNH2MAPTRXFP1ROCK1MAOB | |
| SCHEMBL14864805 | 0.89 | RXFP1 (0.52) | KCNH2MAPTRXFP1ROCK1LMNA | |
| SCHEMBL17067770 | 0.82 | FGFR1 (0.51) | KCNH2MAPTRXFP1ROCK1MAOB | |
| SCHEMBL26652765 | 0.82 | KCNH2 (0.46) | KCNH2MAPTRXFP1ROCK1LMNA | |
| SCHEMBL10296017 | 0.80 | ROCK1 (0.50) | KCNH2MAPTRXFP1ROCK1MAOB | |
| SCHEMBL13183520 | 0.80 | HTR2A (0.45) | KCNH2MAPTRXFP1ROCK1LMNA | |
| SCHEMBL5793352 | 0.80 | MAOB (0.46) | KCNH2MAPTRXFP1ROCK1MAOB | |
| SCHEMBL4572982 | 0.79 | KCNH2 (0.60) | KCNH2MAPTROCK1LMNAEPHX2 | |
| SCHEMBL8736804 | 0.79 | ROCK1 (0.54) | KCNH2MAPTRXFP1ROCK1MAOB | |
| SCHEMBL4295429 | 0.79 | KCNH2 (0.60) | KCNH2CYP19A1BIRC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220089573-A1 | SUBSTITUTED PYRROLIDINE AMIDES III | Grünenthal GmbH (DE) | 2022-03-24 | — | — | US | disclosed |
| US-20200223840-A1 | SUBSTITUTED PYRROLIDINE AMIDES III | GRUENENTHAL GMBH (DE) | 2020-07-16 | — | — | US | disclosed |
| US-RE34299-E | Psychological disorders, neuroleptic agents, analgesics | H. LUNDBECK A/S (DK) | 1993-06-29 | — | — | US | disclosed |
| US-4710500-A | 1-(4'-fluorophenyl)-3,5-substituted indoles useful in the treatment of psychic disorders and pharmaceutical compositions thereof | H. LUNDBECK A/S (DK) | 1987-12-01 | — | — | US | disclosed |
| EP-0200322-A1 | Heterocyclic compounds | H. LUNDBECK A/S (DK) | 1986-11-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200223840-A1 | SUBSTITUTED PYRROLIDINE AMIDES III | NR3C1, NR3C2, MC2R | KCNH2 2896/4885MAPT 4537/4885RXFP1 810/4885 |
| US-20220089573-A1 | SUBSTITUTED PYRROLIDINE AMIDES III | NR3C1, NR3C2, MC2R | KCNH2 2896/4885MAPT 4537/4885RXFP1 810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.