Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 3/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | TEAD1 | P28347 | 7/20 | 0.34 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 6/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | TET3 | O43151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.33 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.33 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.33 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.33 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.33 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22631197 | 0.86 | CHRNB2 (0.38) | KRASJAK3CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL17443386 | 0.78 | — | — | |
| SCHEMBL20343567 | 0.77 | HSD11B1 (0.45) | KRASTEAD1TEAD3JAK3JAK1 | |
| SCHEMBL1463686 | 0.77 | CHRNB2 (0.58) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| SCHEMBL24745958 | 0.76 | — | — | |
| SCHEMBL21393276 | 0.76 | TEAD1 (0.36) | KRASTEAD1JAK3ACHETET3 | |
| SCHEMBL22212872 | 0.76 | — | — | |
| SCHEMBL10138954 | 0.76 | — | — | |
| SCHEMBL16385269 | 0.76 | — | — | |
| SCHEMBL17813669 | 0.76 | TEAD1 (0.36) | KRASTEAD1JAK3ACHETET3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5244899-A | Azabicycloalkyl and azatricycloalkyl amides used to treat inflammation, allergy, asthma and skin disorders | G. D. SEARLE AND CO. (US) | 1993-09-14 | — | — | US | disclosed |
| US-5198435-A | Antiinflammatory, antiallergen | G. D. SEARLE & CO. (US) | 1993-03-30 | — | — | US | disclosed |
| US-5157053-A | Bicycloalky, tricycloalkyl, azabicycloalkyl, and azatricycloalkyl thio amides used to treat inflammation, allergy, asthma and skin disorders | G. D. SEARLE & CO. (US) | 1992-10-20 | — | — | US | disclosed |
| US-5019597-A | Antiinflammatory Agents, Antiallergens | G. D. SEARLE & CO. (US) | 1991-05-28 | — | — | US | disclosed |
| EP-0190684-B1 | BICYCLOALKYL, TRICYCLOALKYL, AZABICYCLOALKYL AND AZATRICYCLOALKYL AMIDES | G.D. Searle & Co. (US) | 1990-07-25 | — | — | EP | disclosed |
| EP-0190684-A2 | Bicycloalkyl, tricycloalkyl, azabicycloalkyl and azatricycloalkyl amides | G.D. Searle & Co. (US) | 1986-08-13 | — | — | EP | disclosed |