Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 4/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12018096 | 0.83 | MAPT (0.48) | MAPTLMNAMEN1KMT2AUSP2 | |
| SCHEMBL9464475 | 0.80 | NPSR1 (0.44) | MAPTLMNAMEN1KMT2AUSP2 | |
| SCHEMBL1018173 | 0.75 | SMN1; SMN2 (0.49) | MAPTLMNAMEN1KMT2AUSP2 | |
| SCHEMBL18687304 | 0.73 | ALDH1A1 (0.46) | MAPTMEN1KMT2AALDH1A1HTT | |
| SCHEMBL9467120 | 0.72 | NPSR1 (0.43) | MAPTLMNAMEN1KMT2AUSP2 | |
| SCHEMBL6320855 | 0.72 | ALDH1A1 (0.53) | MAPTLMNAMEN1KMT2AUSP2 | |
| SCHEMBL11367059 | 0.72 | KDM4E (0.42) | MAPTLMNAMEN1KMT2AUSP2 | |
| SCHEMBL13145702 | 0.72 | MAPT (0.40) | MAPTLMNAMEN1KMT2AUSP2 | |
| SCHEMBL26512859 | 0.71 | KMT2A (0.39) | MAPTLMNAMEN1KMT2AUSP2 | |
| SCHEMBL1020557 | 0.71 | KMT2A (0.52) | MAPTLMNAMEN1KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5258399-A | 5-lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-11-02 | — | — | US | disclosed |
| US-5236948-A | Lipoxygenase inhibitor | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |