Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9464374 | 0.80 | MAPT (0.42) | NPSR1ALDH1A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL17790348 | 0.78 | NPSR1 (0.41) | NPSR1ALDH1A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1007816 | 0.76 | MAPT (0.47) | ALDH1A1MAPT | |
| SCHEMBL8558742 | 0.75 | NPSR1 (0.40) | NPSR1ALDH1A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8488793 | 0.75 | GRIN1 (0.40) | NPSR1ALDH1A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18687304 | 0.75 | ALDH1A1 (0.46) | NPSR1ALDH1A1POLBMAPTMEN1 | |
| SCHEMBL1371755 | 0.74 | NPSR1 (0.44) | NPSR1ALDH1A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13345042 | 0.74 | NPSR1 (0.44) | NPSR1ALDH1A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9467120 | 0.74 | NPSR1 (0.43) | NPSR1ALDH1A1GAALMNAPOLB | |
| SCHEMBL7130212 | 0.73 | S100B (0.38) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5258399-A | 5-lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-11-02 | — | — | US | disclosed |
| US-5236948-A | Lipoxygenase inhibitor | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |