Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.61 |
| ▸ | MGAM | O43451 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | SI | P14410 | 1/20 | 0.54 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | KDM6B | O15054 | 1/20 | 0.48 |
| ▸ | KDM5C | P41229 | 1/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.48 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.48 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL647732 | 0.95 | TSHR (0.68) | TSHRMGAMGAASIMGAM2 | |
| SCHEMBL3266395 | 0.86 | TSHR (0.67) | TSHRMGAMGAASIMGAM2 | |
| SCHEMBL647148 | 0.86 | TSHR (0.65) | TSHRMGAMGAASIMGAM2 | |
| SCHEMBL31578986 | 0.85 | TSHR (0.74) | TSHRMGAMGAASIMGAM2 | |
| SCHEMBL8846311 | 0.85 | KDM4E (0.62) | TSHRMGAMGAASIMGAM2 | |
| SCHEMBL8196189 | 0.84 | TSHR (0.64) | TSHRMGAMGAASIMGAM2 | |
| SCHEMBL31578944 | 0.83 | TSHR (0.70) | TSHRLMNAALDH1A1KDM4ERECQL | |
| SCHEMBL31578856 | 0.83 | TSHR (0.70) | TSHRLMNAALDH1A1KDM4ERECQL | |
| SCHEMBL31579008 | 0.83 | TSHR (0.70) | TSHRLMNAALDH1A1KDM4ERECQL | |
| SCHEMBL11313358 | 0.83 | TSHR (0.70) | TSHRLMNAALDH1A1KDM4ERECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5252603-A | Immunosuppressive analogues and derivatives of succinylacetone | CETUS CORPORATION (US) | 1993-10-12 | — | — | US | disclosed |
| US-5216005-A | Treating autoimmune diseases, organ tissue transplants | CETUS CORPORATION (US) | 1993-06-01 | — | — | US | disclosed |
| US-5173482-A | A dioxoalkyl phosponate or a proline-modified polyoxyethylene glycol derivative; autoimmune diseases; organ transplants; immunoassay | CETUS CORPORATION (US) | 1992-12-22 | — | — | US | disclosed |
| US-4895872-A | TREATING HYPERACTIVE IMMUNE SYSTEMS; AUTOIMMUNE AND GRAFT/HOST DISEASES | CETUS CORPORATION (US) | 1990-01-23 | — | — | US | disclosed |
| WO-1990000049-A2 | IMMUNOSUPPRESSIVE ANALOGUES AND DERIVATIVES OF SUCCINYLACETONE | CETUS CORPORATION (US) | 1990-01-11 | — | — | WO | disclosed |