Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 10/20 | 1.00 |
| ▸ | DRD2 | P14416 | 1/20 | 0.59 |
| ▸ | DRD4 | P21917 | 1/20 | 0.59 |
| ▸ | DRD3 | P35462 | 1/20 | 0.59 |
| ▸ | PARP1 | P09874 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9719779 | 0.99 | SIGMAR1 (0.97) | SIGMAR1DRD2DRD4DRD3PARP1 | |
| SCHEMBL9473840 | 0.96 | SIGMAR1 (0.92) | SIGMAR1DRD2DRD4DRD3PARP1 | |
| SCHEMBL9467083 | 0.86 | SIGMAR1 (0.76) | SIGMAR1DRD2DRD4DRD3PARP1 | |
| SCHEMBL9466872 | 0.85 | SIGMAR1 (1.00) | SIGMAR1DRD2DRD4DRD3PARP1 | |
| SCHEMBL10974243 | 0.84 | SIGMAR1 (0.72) | SIGMAR1DRD2DRD4DRD3PARP1 | |
| Hydrochloric Acid SCHEMBL10937128 | 0.83 | SIGMAR1 (0.71) | SIGMAR1DRD2DRD4DRD3PARP1 | |
| SCHEMBL9466973 | 0.83 | SIGMAR1 (1.00) | SIGMAR1DRD2DRD4DRD3PARP1 | |
| SCHEMBL9377531 | 0.82 | SIGMAR1 (1.00) | SIGMAR1PARP1 | |
| SCHEMBL9467457 | 0.81 | SIGMAR1 (0.68) | SIGMAR1DRD2DRD4DRD3PARP1 | |
| SCHEMBL10970684 | 0.81 | SIGMAR1 (0.67) | SIGMAR1DRD2DRD4DRD3PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5187280-A | Dopaminergic, antipsychotic and antihypertensive agents | WARNER-LAMBERT COMPANY (US) | 1993-02-16 | — | — | US | disclosed |
| US-5118691-A | Substituted tetrahydropyridines as central nervous system agents | WARNER-LAMBERT CO. (US) | 1992-06-02 | — | — | US | disclosed |
| US-5045550-A | Antipsychotic, hypotensive agents, dopaminergic | WARNER-LAMBERT CO. (US) | 1991-09-03 | — | — | US | disclosed |