Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 1.00 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9467081 | 0.87 | SIGMAR1 (0.78) | SIGMAR1TMEM97DRD4DRD2DRD3 | |
| SCHEMBL9466832 | 0.85 | SIGMAR1 (1.00) | SIGMAR1DRD4PARP1DRD2DRD3 | |
| SCHEMBL9719779 | 0.84 | SIGMAR1 (0.97) | SIGMAR1DRD4PARP1DRD2DRD3 | |
| SCHEMBL9467634 | 0.82 | SIGMAR1 (0.69) | SIGMAR1TMEM97DRD4PPARGPPARA | |
| SCHEMBL9473840 | 0.81 | SIGMAR1 (0.92) | SIGMAR1TMEM97DRD4PARP1DRD2 | |
| SCHEMBL9466973 | 0.79 | SIGMAR1 (1.00) | SIGMAR1TMEM97DRD4PPARGPPARA | |
| SCHEMBL9467235 | 0.76 | SIGMAR1 (1.00) | SIGMAR1TMEM97DRD2 | |
| SCHEMBL6969008 | 0.76 | DRD4 (0.61) | SIGMAR1DRD4PPARGPPARADRD2 | |
| SCHEMBL25124555 | 0.75 | SIGMAR1 (0.60) | SIGMAR1DRD4PPARGPPARADRD2 | |
| SCHEMBL10974243 | 0.73 | SIGMAR1 (0.72) | SIGMAR1DRD4PPARGPPARAPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5187280-A | Dopaminergic, antipsychotic and antihypertensive agents | WARNER-LAMBERT COMPANY (US) | 1993-02-16 | — | — | US | claimed |
| US-5187280-A | Dopaminergic, antipsychotic and antihypertensive agents | WARNER-LAMBERT COMPANY (US) | 1993-02-16 | — | — | US | disclosed |
| US-5118691-A | Substituted tetrahydropyridines as central nervous system agents | WARNER-LAMBERT CO. (US) | 1992-06-02 | — | — | US | disclosed |
| US-5045550-A | Antipsychotic, hypotensive agents, dopaminergic | WARNER-LAMBERT CO. (US) | 1991-09-03 | — | — | US | disclosed |