Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL280110 | 0.81 | TSHR (0.58) | PDE3BPDE3ATSHRHTTPLK1 | |
| SCHEMBL653919 | 0.80 | PDE3B (0.51) | PDE3BPDE3ACYP11B2CYP11B1GRM4 | |
| SCHEMBL13780087 | 0.80 | KMO (0.58) | PDE3BPDE3ATSHRHTTKMO | |
| SCHEMBL3332098 | 0.80 | PDE3B (0.51) | PDE3BPDE3ACYP11B2CYP11B1GRM4 | |
| SCHEMBL30991588 | 0.80 | PDE3B (0.51) | PDE3BPDE3ACYP11B2CYP11B1GRM4 | |
| SCHEMBL993713 | 0.80 | PDE3B (0.51) | PDE3BPDE3ACYP11B2CYP11B1GRM4 | |
| SCHEMBL30336556 | 0.80 | PDE3B (0.54) | PDE3BPDE3ACYP11B2CYP11B1GRM4 | |
| SCHEMBL265087 | 0.80 | PDE3B (0.54) | PDE3BPDE3ACYP11B2CYP11B1GRM4 | |
| SCHEMBL1119872 | 0.79 | PDE3B (0.50) | PDE3BPDE3ACYP11B2CYP11B1GRM4 | |
| SCHEMBL762019 | 0.78 | ALDH1A1 (0.61) | PDE3BPDE3ACYP11B2CYP11B1GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260294-A | Treatment of diseases caused by oxidative metabolism of arachidonic acid; antiinflammatory, antiallergins, antiarthriric | HOFFMAN-LA ROCHE INC. (US) | 1993-11-09 | — | — | US | disclosed |
| US-5132310-A | Benzochroman compounds, lipoxygenase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 1992-07-21 | — | — | US | disclosed |
| US-5015661-A | Lipoxygenase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 1991-05-14 | — | — | US | disclosed |