Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.66 |
| ▸ | DRD2 | P14416 | 2/20 | 0.57 |
| ▸ | DRD4 | P21917 | 2/20 | 0.57 |
| ▸ | DRD3 | P35462 | 2/20 | 0.57 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9467457 | 0.96 | SIGMAR1 (0.68) | SIGMAR1DRD2DRD4DRD3PARP1 | |
| SCHEMBL9468037 | 0.83 | SIGMAR1 (0.69) | SIGMAR1DRD2DRD4DRD3HTR1A | |
| SCHEMBL9473840 | 0.81 | SIGMAR1 (0.92) | SIGMAR1DRD2DRD4DRD3PARP1 | |
| SCHEMBL9467898 | 0.80 | SIGMAR1 (0.71) | SIGMAR1DRD2DRD4DRD3PARP1 | |
| SCHEMBL9466832 | 0.80 | SIGMAR1 (1.00) | SIGMAR1DRD2DRD4DRD3PARP1 | |
| SCHEMBL9719779 | 0.79 | SIGMAR1 (0.97) | SIGMAR1DRD2DRD4DRD3PARP1 | |
| SCHEMBL9466769 | 0.76 | SIGMAR1 (0.71) | SIGMAR1DRD2DRD4DRD3PARP1 | |
| Hydrochloric Acid SCHEMBL9154481 | 0.75 | GRIN2B (0.57) | SIGMAR1DRD2DRD4DRD3PARP1 | |
| SCHEMBL9867159 | 0.74 | SIGMAR1 (0.60) | SIGMAR1DRD2DRD4DRD3HTR1A | |
| SCHEMBL9726237 | 0.74 | SIGMAR1 (0.60) | SIGMAR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5120748-A | Substituted 1,2,3,6-tetrahydropyridines as central nervous system agents | WARNER-LAMBERT COMPANY (US) | 1992-06-09 | — | — | US | claimed |
| US-5198443-A | Dopaminergic agents, treatment of schizophrenia | WARNER-LAMBERT COMPANY (US) | 1993-03-30 | — | — | US | disclosed |
| US-5120748-A | Substituted 1,2,3,6-tetrahydropyridines as central nervous system agents | WARNER-LAMBERT COMPANY (US) | 1992-06-09 | — | — | US | disclosed |