SCHEMBL9468751

SCHEMBL9468751

Nc1ccc2c(c1)C(=O)N(c1ccc(Cc3ccc(N4C(=O)c5ccc(N)cc5C4=O)cc3)cc1)C2=O

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CASP1 P29466 3/20 0.71
ALDH1A1 P00352 3/20 0.71
TSHR P16473 3/20 0.71
NPC1 O15118 2/20 0.71
RAB9A P51151 2/20 0.71
HSD17B10 Q99714 2/20 0.71
CASP7 P55210 1/20 0.71
NPSR1 Q6W5P4 2/20 0.60
MEN1 O00255 2/20 0.60
KMT2A Q03164 2/20 0.60
MAPK1 P28482 1/20 0.60
STAT3 P40763 1/20 0.57
ANPEP P15144 2/20 0.50
DPP4 P27487 1/20 0.50
ESR1 P03372 3/20 0.49
ESR2 Q92731 2/20 0.49
FAAH O00519 1/20 0.46
MGLL Q99685 1/20 0.46
NR1H3 Q13133 4/20 0.44
CA12 O43570 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8995319 0.89 CASP1 (0.86) CASP1ALDH1A1TSHRNPC1RAB9A
SCHEMBL9566650 0.88 CASP1 (0.83) CASP1ALDH1A1TSHRNPC1RAB9A
SCHEMBL22111954 0.86 ALDH1A1 (0.70) CASP1ALDH1A1TSHRNPC1RAB9A
SCHEMBL14134849 0.85 ALDH1A1 (0.52) CASP1ALDH1A1TSHRNPC1RAB9A
SCHEMBL10473743 0.85 NR1H3 (0.57) CASP1ALDH1A1TSHRNPC1RAB9A
SCHEMBL15614030 0.83 CA9 (0.61) CASP1ALDH1A1TSHRNPC1RAB9A
SCHEMBL4781427 0.83 ALDH1A1 (1.00) CASP1ALDH1A1TSHRNPC1RAB9A
SCHEMBL12300252 0.82 ALDH1A1 (0.52) CASP1ALDH1A1TSHRNPC1RAB9A
SCHEMBL22681679 0.82 ALDH1A1 (0.52) CASP1ALDH1A1TSHRNPC1RAB9A
SCHEMBL6578947 0.81 ALDH1A1 (0.73) CASP1ALDH1A1TSHRNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5212277-A Engineering plastics KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1993-05-18 US disclosed