Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9469409 | 0.84 | HTR2A (0.45) | HTR2A | |
| SCHEMBL9470035 | 0.81 | CTSD (0.40) | ALDH1A1 | |
| SCHEMBL9469090 | 0.79 | AR (0.47) | HTR2AARALDH1A1MAPTRAB9A | |
| SCHEMBL9469797 | 0.79 | AR (0.47) | ARALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL9469811 | 0.79 | AR (0.47) | HTR2AARALDH1A1MAPTRAB9A | |
| SCHEMBL9469119 | 0.78 | AR (0.54) | ARMAPTKDM4EMEN1GAA | |
| SCHEMBL13964738 | 0.77 | KDM4E (0.53) | ARALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL11699617 | 0.71 | SLC6A2 (0.44) | ARKDM4EMEN1GAAKMT2A | |
| SCHEMBL9469084 | 0.70 | AR (0.47) | ARALDH1A1MAPTGAA | |
| SCHEMBL9469546 | 0.70 | AR (0.47) | ARMAPTKDM4EMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166170-A | 2-(AMINOARYL) INDOLES AND INDOLINES AS TOPICAL ANTIINFLAMMATORY AGENTS FOR THE TREATMENT OF SKIN DISORDERS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-11-24 | — | — | US | claimed |
| US-5214059-A | Dermatitis, psoriasis | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-05-25 | — | — | US | disclosed |
| US-5166170-A | 2-(AMINOARYL) INDOLES AND INDOLINES AS TOPICAL ANTIINFLAMMATORY AGENTS FOR THE TREATMENT OF SKIN DISORDERS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-11-24 | — | — | US | disclosed |
| EP-0406734-A2 | 2-(Aminoaryl)indoles and indolines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-09 | — | — | EP | disclosed |