SCHEMBL9469797

SCHEMBL9469797

Nc1ccc(Cl)cc1C1Cc2ccccc2N1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 1/20 0.47
MAPT P10636 3/20 0.36
GAA P10253 2/20 0.36
CYP3A4 P08684 2/20 0.35
TSHR P16473 2/20 0.35
ALDH1A1 P00352 1/20 0.35
ALOX15 P16050 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
TRPM4 Q8TD43 1/20 0.35
TRPM5 Q9NZQ8 1/20 0.35
ALOX12 P18054 1/20 0.35
CACNB4 O00305 1/20 0.34
CACNA1A O00555 1/20 0.34
CACNA1G O43497 1/20 0.34
CACNG3 O60359 1/20 0.34
CACNA1F O60840 1/20 0.34
CACNA1H O95180 1/20 0.34
CACNB3 P54284 1/20 0.34
CACNA2D1 P54289 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9469027 0.84 HTR3E (0.39) ARMAPTGAATDP1TRPM4
SCHEMBL9469811 0.82 AR (0.47) ARMAPTGAAALDH1A1SMN1; SMN2
SCHEMBL9469090 0.82 AR (0.47) ARMAPTGAACYP3A4ALDH1A1
SCHEMBL9469119 0.81 AR (0.54) ARMAPTGAACYP3A4TSHR
SCHEMBL9469064 0.79 HTR2A (0.45) ARMAPTGAAALDH1A1KDM4E
SCHEMBL9469366 0.79 AR (0.44) ARMAPTGAACYP3A4TSHR
SCHEMBL9470035 0.79 CTSD (0.40) ALDH1A1ALOX12L3MBTL1CTSD
SCHEMBL9469084 0.73 AR (0.47) ARMAPTGAAALDH1A1L3MBTL1
SCHEMBL9469546 0.73 AR (0.47) ARMAPTGAACYP3A4ALOX15
SCHEMBL9469019 0.72 RAB9A (0.46) ARMAPTGAATSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5166170-A 2-(AMINOARYL) INDOLES AND INDOLINES AS TOPICAL ANTIINFLAMMATORY AGENTS FOR THE TREATMENT OF SKIN DISORDERS HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1992-11-24 US claimed
EP-0406734-A2 2-(Aminoaryl)indoles and indolines, a process for their preparation and their use as medicaments HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1991-01-09 EP claimed
JP-3044370-A None JP disclosed
US-5214059-A Dermatitis, psoriasis HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1993-05-25 US disclosed
US-5166170-A 2-(AMINOARYL) INDOLES AND INDOLINES AS TOPICAL ANTIINFLAMMATORY AGENTS FOR THE TREATMENT OF SKIN DISORDERS HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1992-11-24 US disclosed
JP-H0344370-A 2-(AMINOARYL) INDOLE AND INDOLINE, AND PREPARATION THEREOF HOECHST ROUSSEL PHARMACEUT INC 1991-02-26 JP disclosed
EP-0406734-A2 2-(Aminoaryl)indoles and indolines, a process for their preparation and their use as medicaments HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1991-01-09 EP disclosed